High Purity Natural 17A-Estradiol / CAS No.: 57-91-0

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High Purity Natural 17A-Estradiol / CAS No.: 57-91-0
Product name:High Purity Natural 17a-Estradiol
CAS No.: 57-91-0
Other Names: 17a-Estradiol; Estra-1,3,5(10)-triene-3,17a-diol
MF: C18H24O2
EINECS No.: 200-354-8
Type: Endocrine System Agents
Grade Standard: Medicine Grade
Purity: 98%
Synonyms: 17a-Estradiol (8CI); 1, 3, 5-Estratriene-3, 17a-diol; 13b-Methyl-1, 3, 5(10)-gonatriene-3, 17a-diol; 17-Epiestradiol; 17a-Oestradiol
CAS No.: 57-91-0
ECNECS NO: 200-354-8
MF: C18H24O2
MW: 272.38
Purity: 99.3% min.
Density: 1.17 g/cm3
Melting Point: 176-180 ° C(lit. )
Boiling Point: 445.9 ° C at 760 mmHg
Refractive Index: 1.599
Flash Point: 209.6 ° C
Appearance: White Powder
Grade: Pharmaceutical Grade
Storage: Shading, confined preservation

Specification:
Product name High Purity Natural 17a-Estradiol
CAS No.: 57-91-0
Assay ≥99.0%
Appearance White or white crystalline powder
MF. C18H24O2
MW. 272.39
EINECS 200-354-8
Usage: 17α -estradiol is a 5α -reductase inhibitor used topically for the treatment of androgenic alopecia (hair loss) in men and women.

Usage:
Estradiol (known as α -Estradiol or 17 α -Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-stradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer's disease and ischemic stroke.

A university-led study (including several authors who are advisors to companies) in 103 women comparing alfatradiol to minoxidil, another topical hair loss treatment, found the latter to be more effective. In contrast to minoxidil, alfatradiol did not result in an increase of hair density or thickness, but only in slowing down or stabilization of hair loss in this study. In an earlier study, no systemic side effects were noted, and 17α -estradiol was found to reduce androgenic hair loss, though it was not effective at growing new hair.

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