Progesterone Hormones Drospirenone Powder

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Progesterone Hormones Drospirenone Powder
Alias: 6b,7b:15b,16b-Dimethylen-3-oxo-17a-pregn-4-ene-21,17-carbolactone; Dihydrospirorenone
CAS NO:67392-87-4
Molecular weight:366.49
Molecular formula:C24H30O3
EINECS No.: 266-679-2
Assay: 99%
Packing: foil bag
Appearance: White crystalline powder
CAS Registry Number 67392-87-4
EINECS 266-679-2
Molecular Structure
Density 1.26g/cm 3
Melting point 196-200°C
Boiling point 552.2°C at 760 mmHg
Refractive index 1.61
Flash point 241.6°C
Vapour Pressure 3.07E-12mmHg at 25°C

Description:
Drospirenone (INN, USAN), also known as 1, 2-dihydrospirorenone, is a synthetic hormone used in birth control pills and postmenopausal hormone replacement therapy pills.
It is sold under the brand names Yasmin, Yasminelle, Yaz, Beyaz, Ocella, Zarah, Daylette and Angeliq, all of which arecombination products of drospirenone with an estrogen such as ethinylestradiol or estradiol.
Drospirenone differs from other synthetic progestins in that its pharmacological profile in preclinical studies shows it to be closer to the natural progesterone. As such it has potent antimineralocorticoid properties, counteracts the estrogen-stimulated activity of the renin-angiotensin-aldosterone system, and has also been shown to possess mild antiandrogen activity.
The antimineralocorticoid properties exhibited by drospirenone promote sodium excretion and prevent water retention.

Application:
Drospirenone is an ingredient in some birth control pills and hormone replacement therapy. In combination with ethinyl estradiolit is used as contraception, and for women who want contraception it is also approved by the U. S. Food and Drug Administration(FDA) to treat moderate acne and premenstrual dysphoric disorder.

Specification:
Description White or almost white power Almost white power
Identification 1. Specific rotation 2. IR Conforms Conforms
Specific rotation -187.0°~ -193.0° -192.3°
Loss on drying ≤0.5% 0.23%
Related Substances Unspecified impurity <0.10% Total impurities ≤0.3% 0.09% 0.27%
Assay(Dry Basis) 98.0%~102.0% 99.0%
Conclusion Passed



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