Synthetic Adrenocortical Steroid Dexamethasone Sodium Phosphate For Acute Disorders CAS 55203-24-2

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Synthetic Adrenocortical Steroid Dexamethasone Sodium Phosphate For Acute Disorders CAS 55203-24-2

1.Production Details
Product Name: Dexamethasone sodium phosphate Alias: Betamethasone Sodium Phosphate
CAS No: 2392-39-4 Purity: 99%
Apperance: White powder Application: Pharmaceutical intermediates

Dexamethasone is a corticosteroid hormone (glucocorticoid). This injectable form of dexamethasone is used when a similar drug cannot be taken by mouth or when a very fast response is needed, especially in patients with severe medical conditions


2.Specifications(coa and HPLC)

Product name Dexamethasone Sodium Phosphate
CAS register number 2392-39-4
EINECS NO 219-243-03
MF C22H28FNa2O8P
Quality standard CP2010 / EP6 / USP32
Purity 99% ~ 102.0%
Specific rotation + 72 ° to + 80 °
pH 7.5-10.5

3.Usage

As an anti-inflammatory medication. Dexamethasone relieves inflammation in various parts of the body. It is used specifically to decrease swelling (edema), associated with tumors of the spine and brain, and to treat eye inflammation.
To treat or prevent allergic reactions.
As treatment of certain kinds of autoimmune diseases, skin conditions, asthma and other lung conditions.

As treatment for a variety of cancers, such as leukemia, lymphoma, and multiple myeloma.
To treat nausea and vomiting associated with some chemotherapy drugs.
Used to stimulate appetite in cancer patients with severe appetite problems.
Also used to replace steroids in conditions of adrenal insufficiency (low production of needed steroids produced by the adrenal glands).


4.Precautions

Before starting dexamethasone treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, or products containing aspirin unless your doctor specifically permits this.
Do not receive any kind of immunization or vaccination without your doctor's approval while taking dexamethasone.

If you have been on dexamethasone pills daily, for a long period of time, serious side effects may occur if you discontinue the medication abruptly. Do not stop taking this medication unless directed by your healthcare provider. Do not change the dose of dexamethasone on your own.
Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category C (use in pregnancy only when benefit to the mother outweighs risk to the fetus).

For both men and women: Do not conceive a child (get pregnant) while taking dexamethasone. Barrier methods of contraception, such as condoms, are recommended. Discuss with your doctor when you may safely become pregnant or conceive a child after therapy.
Do not breast feed while taking this medication.

5.Some of the usual single doses are

Site of Injection Amount
Phosphate (mg)
Large joints (e.g., Knee) 2 to 4
Small joints (e.g., Interphalangeal, Temporomandibular) 0.8 to 1
Bursae 2 to 3
Tendon sheaths 0.4 to 1
Soft tissue infiltration 2 to 6
Ganglia 1 to 2

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever the solution and container permit.
Dexamethasone Sodium Phosphate injection, USP is particularly recommended for use in conjunction with one of the less soluble, longer-acting steroids for intra-articular and soft tissue injection.

6.Overdosage

Reports of acute toxicity and/or death following overdosage of glucocorticoids are rare. In the event of overdosage, no specific antidote is available; treatment is supportive and symptomatic.
The oral LD50 of dexamethasone in female mice was 6.5 g/kg. The intravenous LD50 of Dexamethasone Sodium Phosphate in female mice was 794 mg/kg.
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7.Functions

Corticosteroids are naturally produced by the adrenal gland in the body. Corticosteroids influence the functioning of most of the body's systems (heart, immune, muscles and bones, endocrine and nervous system). They exert a wide array of effects including effects on the metabolism of carbohydrates, protein and fats. They help to maintain balance of fluids and electrolytes.
Dexamethasone is classified as a corticosteroid (more precisely a glucocorticosteroid), and has many uses in the treatment of cancer.

One way that it works is to decrease inflammation (swelling). It does this by preventing infection- fighting white blood cells (polymorphonuclear leukocytes) from traveling to the area of swelling in your body. (This is why you are more prone to infection while taking steroids). Taking advantage of the anti-inflammatory properties of the medication, corticosteroids are used to decrease the swelling around tumors. For example, by decreasing swelling around tumors in the spine, brain, or bone, it can decrease the pressure of the tumor on nerve endings and relieve pain or other symptoms caused by the pressing tumor.
Another way this drug works is by altering the body's normal immune system responses. Corticosteroids are used to treat certain conditions that effect the immune system such as aplastic anemia (AA), Immune Thrombocytopenia Purpura (ITP), Thrombotic Thrombocytopenia Purpura (TTP), or hemolytic anemia.

In addition, it is thought that corticosteroids may help in the treatment of patients with blood disorders, such as multiple myeloma. Corticosteroids may work by causing programmed cell death (apoptosis) of certain cells, which may help to fight your disease.
Dexamethasone is also used in the short-term treatment of nausea caused by chemotherapy. How it does this is not fully understood. It also has been used to stimulate appetite for patients with severe appetite problems.

Corticosteroids are used to replace steroids in conditions of adrenal insufficiency (low production of needed steroids produced by the adrenal glands).
Note: We strongly encourage you to talk with your health care professional about your specific medical condition and treatments. The information contained in this website is meant to be helpful and educational, but is not a substitute for medical advice.



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