99% 17A-Hydroxyprogesterone White Crystalline Powder

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99% 17A-Hydroxyprogesterone White Crystalline Powder
Product name: 17A-hydroxyprogesterone
Synonyms: 17-Alpha-Hydroxy-Progesterone
CAS: 68-96-2
Packaging: 1kg/bag
Assay: 99%
Packing:Aluminium Foil Bag or as Required
Molecular Formula: C21H30O3
Molecular weight: 330.47
Appearance: White or white crystalline powder
Loss On Drying 0.5%max 0.26%
Melting Point 276° C 276° C
Residue On Ignition 0.1%max 0.06%
Heavy Metals 10PPm max <10PPm

How is it used?
The 17-hydroxyprogesterone (17-OHP) test is routinely ordered as part of newborn screening in the UnitedStates to detect congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. CAH is a group ofinherited disorders caused by specific gene mutations and associated with cortisol-related enzymedeficiencies. About 90% of CAH cases are caused by a mutation in the 21-hydroxylase gene (also calledP450c1 or CYP21A2) and may be detected due to the accumulation of 17-OHP in the blood.
The 17-OHP test may be used to screen for CAH in older children or adults before symptoms appear or toconfirm a CAH diagnosis in people with symptoms.

17-OHP testing may produce false-positive test results. If the level is elevated but not so high that it isdiagnostic of CAH, other tests may be performed, such as androstenedione and testosterone. An ACTHstimulation test may be also be ordered as a follow-up test (in CAH, ACTH stimulation will markedlyincrease 17-OHP levels). Molecular genetic testing may be performed to detect CYP21A2 gene mutations thatcan cause the condition. A karyotype test may be ordered as a follow-up test to detect chromosome disordersand to help determine a baby's sex. Electrolytes may be ordered to measure the person's sodium andpotassium levels.



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