Megestrol acetate

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Megestrol acetate
Product Name:Megestrol acetate
CAS:595-33-5
MF:C24H32O4
MW:384.51
EINECS:209-864-5
mp:214¡ãC
Megestrol acetate refractive index:11¡ã(C=2, CHCl3)
Megestrol acetate Chemical Properties:Crystalline Solid
Megestrol acetate Usage:Progestogen;Progesterone receptor agonist,Orally active progestogen; formerly used in combinations as oral contraceptive,treatment of endometrial hyperplasia

Megestrol acetate COA
Test Items Specification Test Results
Appearance White to creamy white crystalline powder White crystalline powder
Identification IR Complies
Completeness of solution Meets the requirements.500mg being Complies
dissolved in 10ml of acetone
Solubility Insoluble in water, sparingly soluble in Complies
alcohol. Slightly soluble in ether and in
fixed oils, soluble in acetone; very soluble
in chloroform.
Melting range 213ºC~220ºC 217ºC
Specific optical rotation +8.8°~ +12.0° +11.6°
Water ≤0.5% 0.1%
Residue roration ≤0.2% 0.06
Heavy metals ≤0.002% Complies
Assay 97.0%~103.0% 99.6%
Residual solvents Methanol≤1000ppm 74ppm
Ethanol≤1000ppm 39ppm
Methylene chloride≤500ppm 28ppm
Tetrahydrofuran≤300ppm ND
Benzene≤2ppm ND


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