Superior Antiandrogen Cyproterone Acetate CAS 427-51-0 for Male Contraceptive



Superior Antiandrogen Cyproterone Acetate CAS 427-51-0 for Male Contraceptive

1. Quick Detail:
Cyproterone acetate
Synonyms: 1, 2-alpha-methylene-6-chloro-delta-(sup4, 6)-pregnadiene-17-alpha-ol-3, 20-dio
Inchi: InChI=1/C24H29ClO4/c1-12(26)24(29-13(2)27)8-6-16-14-10-20(25)19-11-21(28)15-9-18(15)23(19, 4)17(14)5-7-22(16, 24)3/h10-11, 14-18H, 5-9H2, 1-4H3/t14-, 15+, 16-, 17-, 18-, 22-, 23-, 24-/m0/s1
CAS No.: 427-51-0
ECNECS No.: 207-048-3
MF: C24H29ClO4
MW: 416.94
Purity: 99%
Density: 1.27 g/cm3
Melting Point: 200-201oC
Boiling Point: 525.9oC at 760 mmHg
Vapour: 3.78E-11mmHg at 25° C
Refractive Index: 1.582
Flash Point: 177.6 oC
Appearance: White crystalline powder
Grade: Pharmaceutical Grade
Storage: Shading, confined preservation
Lead time: Within 12 hours upon receipt of payment
Delivery: EMS, DHL, TNT, FedEx, UPS
Usage: Anti-androgen for the treatment of men with BPH, and can be used as male contraceptive

2. Product description:
Cyproterone acetate, is a synthetic steroidal antiandrogen, progestin, and antigonadotropin. It is primarily used in the treatment of androgen-related conditions by virtue of its ability to suppress androgenic activity in the body, an effect which it mediates by preventing endogenous androgens from interacting with the androgen receptor and by suppressing androgen biosynthesis. CPA is also used for its progestogenic effects, for instance, as a component of some combined oral contraceptive pills, such as in Dianette in the United Kingdom, Diane-35 in Canada, Bella Hexal in Germany, Diane in Sweden, and Dixi-35 in Chile.

3. Application:
As an oral contraceptive, 2 mg CPA is combined with 35 or 50 mcg ethinyl estradiol and taken once daily for 21 days, followed by a 7 day free interval.
For the treatment of hypersexuality, severe hirsutism, or for the treatment of trans women, 25 mg twice daily is usually sufficient, although up to 100 mg per day is permitted. As side effects are dose-dependent, treatment with the lowest effective dose is advisable.
Use during pregnancy is contraindicated, and for women of childbearing age, CPA should be administered with a combined oral contraceptive. To ensure that it does not interfere with regular withdrawal bleeding, additional CPA should be taken only on days 1-10 of a 28-day package of birth control pills.
Doses up to 300 mg/day are used for the treatment of metastatic prostate cancer, but at high doses the risk of serious hepatotoxicity and adrenal suppression requires careful monitoring. In the treatment of prostate cancer, CPA is often co-administered with a GnRH agonist and a 5α -reductase inhibitor.

4.Cyproterone acetate (INN, USAN, BAN, JAN), sometimes abbreviated as CPA, and sold under brand names such as Androcur and Cyprostat, is a synthetic steroidal antiandrogen drug with additional progestogen and antigonadotropic properties. Its primary action is to suppress the activity of the androgen hormones such as testosterone and its more potent metabolite dihydrotestosterone (DHT) in the body, effects which it mediates via competitive antagonism of the androgen receptor and inhibition of enzymes in the androgen biosynthesis pathway. The main therapeutic indications of cyproterone acetate are prostate cancer, benign prostatic hyperplasia, priapism, hypersexuality (e.g., as a form of chemical castration), and other conditions in which androgen action maintains the disease process. In addition, it can also be used to treat acne and hirsutism in females, and is a common component in hormone therapy for transsexual women.
In addition to its antiandrogen properties, cyproterone acetate has weak progestogen activity (i.e., it acts like progesterone). Accordingly, it can be used to treat hot flashes, and is also a component of some combined oral contraceptive pills such as Dianette in the United Kingdom and Diane-35 in other countries such as Canada. It is called Dixi-35 in Chile. No form of cyproterone acetate is available in the United States.
Until the development of leuprorelin, cyproterone acetate was one of the few drugs used to treat precocious puberty. It was also used in animal experimentation to investigate the actions of androgens in fetal sexual differentiation.


Product name Cyproterone acetate
Appearance White crystalline powder
Water ¡Ü3% pass
Assay 99.0% 99.3%
Loss on drying ¡Ü0.5% 0.1%
Related substances total impurities ¡Ü1.0% Pass
any individual impurity ¡Ü0.5% Pass
Residual solvents ethanol ¡Ü0.5% Pass

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