Trilostane 99% CAS 13647-35-3 for Breast Cancer Treatment



Trilostane 99% CAS 13647-35-3 for Breast Cancer Treatment
·Synonym: Vetoryl
·CAS Registry Number:13647-35-3
·Einecs No:237-133-0
·Grade : Pharmaceutical Grade
·Storage: Shading, confined preservation
·Appearance:: White crystalline powder
·Manufacturer :Hezhong
·Usage : Trilostane can inhibit cortical hormone in the process of synthesis of 3 beta dehydrogenase, make the cortisol, aldosterone synthesis decreased, clinically used in the treatment of Cushing syndrome (hypercortisolism) and primary aldosteronism. This product also had significantly effect to decreased serum testosterone level.

Product Description:

product Name Trilostane
Synonyms 17-hydroxy-3-oxo-4,5-epoxyandrostane-2-carbonitrile; (4alpha,5alpha,17beta)-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile
Molecular Formula C20H27NO3
Molecular Weight 329.4333
Molecular structure
CAS Registry Number 13647-35-3
EINECS 237-133-0
Density 1.28g/cm3
Melting point 264¡ãC
Boiling point 497.8¡ãC at 760 mmHg
Refractive index 1.61
Flash point 254.8¡ãC
Vapour Pressur 5.39E-12mmHg at 25¡ãC


Trilostane is used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible.

Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Trilostane reduces the amount of steroids produced by the adrenal gland.

Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.

Side effect:Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting.


Tests Specifications Results
Identification Positive Confirm
Melting point 257¡ãC to 270¡ãC 261¡ãC -266¡ãC
Appearance White to pale white solid White solid
Heavy metals No more than 20ppm 10ppm
Loss on drying Not more than 0.5% 0.18%
Residue on Ignition Not more than 0.1% 0.02%
Solubility soluble in dimethyl sulfoxide Conforms
soluble in pyridine Conforms
slightly soluble in ethanol Conforms
slightly soluble in water Conforms
Assay (microbial) Not less than 99.0% 99.5%
Specific Rotation +137-139¡ã 137.0¡ã
Related impurities not more than 1.0% 0.35%
HPLC purity not less than 99.0% 99.6%
Solvent Residues Ethanol<5000ppm 1000ppm
Conclusion Comply with In-house standard.
Storage Store protected from light and moisture

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