Mevastatin

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Product Name: Mevastatin
Synonyms: ML-236B;,8-beta(2s*,4s*),8a-beta))-;antibioticml236b;butanoicacid,2-methyl-,1,2,3,7,8,8a-hexahydro-7-methyl-8-(2-(tetrahydro-4-hy;compactin(penicillium);droxy-6-oxo-2h-pyran-2-yl)ethyl)-1-naphthalenylester,(1s-(1-alpha(r*),7-beta;ml236blactone;6-DEMETHYLVEVINOLIN
CAS: 73573-88-3
MF: C23H34O5
MW: 390.51
EINECS:
Product Categories: Active Pharmaceutical Ingredients;Various Metabolites and Impurities;Metabolites;Pharmaceuticals;HMG-CoA reductase;Intermediates & Fine Chemicals;Metabolites & Impurities;Cardiovascular APIs

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mp 151-153 °C
storage temp. 2-8°C
solubility DMSO: 20 mg/mL
form powder
color white
Merck 13,6186

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Chemical Properties Off-White Solid
Usage A fungal metabolite which is a potent inhibitor of HMG-CoA reductase.
Usage antihyperlipidemic, HMGCoA reductase inhibitor
Usage Mevastatin (compactin) is a diterpene produced by several species of the genera Penicillium and Monascus, first reported in 1976. Mevastatin, the prtotype of the statin class, is a potent competitive inhibitor of HMG-CoA reductase, a regulatory enzyme for cholesterol biosynthesis. Mevastatin has also been shown to induce apoptosis by inhibiting post-translational prenylation of proteins such as Ras, increasing eNOS mRNA and protein levels by blocking the geranylgeranylation of Rho, and inhibiting myoblast fusion. It induces cell cycle arrest in late G1 phase and may induce bone morphogenic protein-2 (BMP-2).
Usage anti-hyperlipoproteinemic, 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitor
Usage Mevastatin (compactin) is a diterpene produced by several species of the genera Penicillium and Monascus, first reported in 1976. Mevastatin, the prototype of the statin class, is a potent competitive inhibitor of HMG-CoA reductase, a regulatory enzyme for cholesterol biosynthesis. Mevastatin has also been shown to induce apoptosis by inhibiting post-translational prenylation of proteins such as Ras, increasing eNOS mRNA and protein levels by blocking the geranylgeranylation of Rho, and inhibiting myoblast fusion. It induces cell cycle arrest in late G1 phase and may induce bone morphogenic protein-2 (BMP-2).

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