99% Purity Local Anesthetics Drugs CAS 637-58-1 Pramoxine Hydrochloride Pharmaceutical Raw Materials 13649-88-2 Deflazacort

99% Purity Local Anesthetics Drugs CAS 637-58-1 Pramoxine Hydrochloride


Quick Detail :
 
Product Name: Pramoxine hydrochloride 
Synonyms: 4-(3-(p-butoxyphenoxy)propyl)-morpholinhydrochloride;gamma-morpholinopropyl4-n-butoxyphenyletherhydrochloride;p-butoxyphenylgamma-morpholinopropyletherhydrochloride;proctofoam;PRAMOXINE HCL;PRAMOXINE HYDROCHLORIDE;PRAXOMINE HYDROCHLORIDE;TRONOTHANE HYDROCHLORIDE 
CAS: 637-58-1 
MF: C17H28ClNO3 
MW: 329.86 
EINECS: 211-293-1
Purity: 99% min 
Related categories: pharmaceutical and bio chemical drug; autonomic nervous system; fine chemicals; API;YUTOPAR; pharmaceutical intermediates; local anesthesia series
Appearance : White powders
Usage : 1. muscle relaxant (smooth) 
        2. slows growth of unwanted facial hair 
        3. Local anesthetics
 
Description :

Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic discovered at Abbott Laboratories in 1953 and used as an antipruritic. Chemically, it is p-n butoxyphenyl gammamorpholinopropyl ether hydrochloride. During research and development, pramoxine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent.Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in humans. Like other local anesthetics, paramoxine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness.

 

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