99% Sarm Steroids Powder 2627-69-2 Regulating Agents Aicarilding Sarms 431579-34-9 Selective Androgen Receptor Modulators Yk11

99% SARM Steroids Powder 2627-69-2 Regulating Agents AICAR


Quick Detail : 

Acadesine
Alias: AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE 
CAS: 2627-69-2 
EINECS: 220-097-5 
Molecular Formula: C9H14N4O5 
Molecular Weight: 258.23 
Assay: 99% 
Apperance: White or off-white powder. 
Usage: Pharmaceutical intermediates. For the treatment of cardiovascular diseases

Description :

SARM AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK) , a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes . In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.

Application :
 
Exercise improves insulin sensitivity.
a single dose of AICAR leads to an apparent enhancement in whole-body, muscle, and liver insulin action in HF rats that extends beyond the expected time of AMPK activation. Whether altered tissue lipid metabolism mediates AICAR effects on insulin action remains to be determined. the results suggest that pharmacological activation of AMPK may have potential in treating insulin-resistant states and type 2 diabetes

 

 

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