98% Min Legal Prohormones Steroids Powders 84371-65-3 Mifepristone Drug Steroids

98% min Legal Prohormones Steroids Powders 84371-65-3 Mifepristone Drug Steroids For Anti - Progesterone


Quick Detail :
 
Product Name: Mifepristone
Synonyms: 11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)-estra-9-dien-3-one;11beta-[4-(n,n-dimethylamino)phenyl]-17alpha-(prop-1-ynyl)-delta4,9-estradiene;17-beta)-(11-bet;17beta)-11-[4-(dimethylamino)-phenyl]-17-hydroxy-17-(1-propynyl)estra-(11bet;17-beta-hydroxy-11-beta-(4-dimethylaminophenyl-1)-17-alpha-(prop-1-ynyl)oest;-17beta-ol-3-one;4,9-dien-3-one;r38486
CAS: 84371-65-3
MF: C29H35NO2
MW: 429.59
Product Categories:Steroids;Hormone;Acetylenes;Biochemistry;
Functionalized Acetylenes;Hydroxyketosteroids;Chiral Reagents;
Intermediates & Fine Chemicals;Pharmaceuticals;Intracellular receptor;Nuclear Receptors;Steroid and Hormone;API;Hormone Drugs
MP 195-198°C
Storage temp. 2-8°C
Chemical Properties : Pale Yellow Solid
Usage : A progesterone receptor antagonist with partial agonist activity. Abortifacient.
Usage : glutamate uptake inhibitor, AMPA blocker

Description :
 
Mifepristone belongs to the anti-progesterone drug. It was first successfully developed by the French company Roussel-Uolsf in the early 1980s for acting as a novel anti-fertility drug acting at receptor levels. It has no progesterone, testosterone, estrogen activity. It first entered into market in France at 1988 with its major role in acting on the endometrial progesterone receptor which is capable of binding with the progesterone receptor and glucocorticoid receptor with high affinity. The affinity to the endometrial progesterone receptor of it is five time as strong as that of progesterone without significant effects on the cortisol levels, and can produce a strong anti-progesterone effect thus causing the degeneration of decidua and chorionic villi of pregnancy. It can also cause release of endogenous prostaglandins which causes uterine contractions while resulting in the decreased production of the human chorionic gonadotropin hormones and dissolution of corpus luteum, and finally causing the embryo abortion. Because the drug can't trigger enough uterine activity so single application for anti-pregnancy yields a relative high rate of incomplete abortion, but it can increase uterine sensitivity to prostaglandins, so that it not only reduces the adverse effects of prostaglandins after adding a small dose of prostaglandin but also make the complete abortion rate increased significantly. In addition mifepristone also has a softening and expansion effect of the cervix .
 

 

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