Tadalafil Citrate (Cialis)

Product Name: Tadalafil Citrate (Cialis)

CAS No.: 171596-29-5

Purity: 99%

Appearance: White crystalline powder

Melting Point: 300°C ~303°C

Loss on drying: NMT 0.5%

Heavy metals(Pb): NMT 20ppm

Residue on ignition: NMT 0.1%

Relative substance: NMT 1.0%

Assay (on dried basis): NLT 98.5%

Standard: USP36

Details:

Tadalafil is a PDE5 inhibitor marketed in pill form for treating erectile dysfunction (ED) under the name Cialis, and under the name Adcirca for the treatment of pulmonary arterial hypertension.

Although sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis) all work by inhibiting PDE5, tadalafil's pharmacologic distinction is its longer half-life (17.50 hours) – compared to sildenafil (4.0–5.0 hours) and vardenafil (4.0–5.0 hours) – resulting in longer duration of action, and so partly responsible for "The Weekend Pill" sobriquet. Furthermore, the longer half-life is the basis for current investigation of tadalafil's daily therapeutic use in relieving pulmonary arterial hypertension. Sildenafil is approved in several world regions as a thrice-daily therapy for pulmonary arterial hypertension.



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