医药中间体

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PEG-MGF Molecular Formula : C121H200N42O39
PEG-MGF Molecular Weight : 2867.2
PEG-MGF CAS No. : N/A
PEG-MGF Sequence: Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln- Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys-NH2
Physical Apperance
white powder
Form & Formulations
Sterile Filtered white lyophilized (freeze-dried)
Stability
2 months at room temperature 24 months from date of receipt, ­20 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, ­20 to ­70 °C under sterile conditions after reconstitution.
Suitability
suitable for cell culture and animal experiment
Purity
>98% by RP-HPLC
Storage
Store at -20°C. Product is guaranteed 2 years from the date of shipment. Following reconstitution, store at -20°C. We recommend to add a carrier protein (0.1% HSA or BSA) for long term storage.

PEG-MGF (mechano growth factor-pegylated) is a variant of IGF-1 (Insulin-like Growth Factor) which leads to an increase in the muscle cells of the muscles needed for adults to continue to grow beyond their genetic limit. Like other forms of IGF-1, PEG-MGF (also known as IGF-1EC) creates new muscle cells and stimulates muscle growth by promoting nitrogen retention and increasing protein synthesis.
PEG-MGF differs from regular MGF since it has undergone a process of "pegylation" which prolongs its half-life of less than 30 minutes to several days.

Useful for : People who seek to stimulate muscle growth (usually late).

Storage: The vials are lyophilized and will therefore remain stable at room temperature for 1-2 months. However, for long-term storage, they must be kept a 2-8 degrees C (refrigerator temperature), where they will remain stable until 18 months in powder form. Once mixed with mixing solution, vials should be stored in the refrigerator and not left at room temperature.

NOTEDo not mix all your bottles at a time. You have to mix 1 bottle at a time and leave the rest in powder form until you are ready to use the next bottle.

When to take : Injecting the product after your weight training session. Make a single injection into a muscle group, or to 2 injections into the left and right side muscles (eg if you inject 200 mcg per day, you have to 100 100 mcg mcg left side and right side).

How to : Preferably injected intramuscularly. But because of the long half-life, it can be injected under the skin into the fat (belly, thigh or buttocks) and still make its way to the receptors on muscle cells and be effective. Other peptides can be mixed in the same syringe and injected at the same time.

PEG-MGF, or PEGylated Mechano Growth Factor is a new and innovative form of MGF that outperforms natural MGF many times over. MGF is a splice variant of the IGF gene which increases stem cell count in the muscle and allows for muscle fibers to fuse and mature. This is a process required for growth of adult muscle. Natural MGF is made locally and does not travel into the bloodstream. Synthetic MGF is water based and when administered intramuscularly, travels into the bloodstream. MGF is only stable in the blood stream for only a few minutes.

PEGylation is the act of attaching a Polyethylene glycol (PEG) structure to another larger molecule (in this case, MGF). The PEG acts as a protective coating and the theory here is that this will allow the MGF to be carried through the blood stream without being broken down.

MGF exhibits local effects in skeletal muscle and without cannot travel through the body without modification. The problem with synthetic MGF is that it is introduced intramuscularly and is water based so it goes into the blood stream. When used this way, MGF only remains stable in the blood stream for a few minutes. Biologically produced MGF is made locally and does not enter the bloodstream. It is also short acting so stability is not an issue. By PEGylating the MGF it is almost as efficient as local produced MGF when used intramuscularly. This is accomplished by surrounding part of the peptide with a structure of polyethylene glycol, which can be attached to a protein molecule. The polyethylene glycol groups protect the peptide but don’t surround it completely. The active sites of the peptide are still free to do their biological function. In this case the shell is a negative charged shield against positively charged compounds that would affect the protein. T
Neurological research has shown that utilizing PEGylated MGF resulted in a longer more stable acting version of the MGF peptide in serum/blood.

Why Mechano Growth Factor? Resistance training or more specifically, a training that causes our muscles to work beyond their usual power leads to that familiar ‘burning’ sensation we all have had a chance to experience during an exercise. What happens to our muscles at that point is the following: Every muscle is a cluster of muscle fibers (muscle cells), which at the point of extreme efforts tend to tear. The tearing of the muscle fibers is what causes the burning sensation. The torn parts form certain ‘cavities’ in the muscle tissue and those cavities represent a chance for a muscle to grow. After those ‘cavities’ are filled up with the muscle ‘matter’, we are left with a muscle of an increased mass. Why ‘Mechano’? Because tearing of the muscle fibers is an actual mechanical damage, and the only way to achieve that kind of damage is through mechanical stimulation of the muscle tissue. Why ‘Growth Factor’? Because Mechano Growth Factor is responsible for accelerated muscle build-up processes. Besides accelerating muscle build-up processes Mechano Growth Factor also helps create new muscle cells. That’s a simplified way of looking at the whole process.



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