CAS 87616-84-0 GHRP-6


CAS 16941-32-5 Glucagon

99% Polypeptide Hormones Glucagon CAS 16941-32-5 Human Glucagon For Promoting Insulin & Islet Somatostatin

Glucagon(1-29)(Human)
Sequence:H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH
Alias:Glucagon(pig),Bovineglucagon,Glucagon(Canisfamiliaris stomach),Glucagon(Mesocricetus auratus),Glucagon(Saimirisciureus),Glucagon(Xenopus aevis),Glucagon (dog pancreas),Glucagon (dog),Glucagon (human),Glucagon (ox), Glukagon Novo, Human glucagon
Cas No. : 16941-32-5
Molecular Formula : C153H225N43O49S
Molecular Weight: 3482.75
Purity (HPLC) : 99.0%min.
Appearance: White powder
Single Impurity (HPLC): 0.5%max
Amino Acid Composition: ±10% of theoretical
Peptide Content (N%): >75.0%
Water Content(Karl Fischer): <8.0%
HCl Content (HPIC): <10.0%
Specific Rotation (20/D): -37.0~-47.0°(c=1 1%HAc
Grade : Pharmaceutical Grade
Storage: Closed, below 2 ~ 8℃ preservation
Usage : Glucagon is a promoting hormone catabolism, glucagon has very strong promoting glycogenolysis and gluconeogenesis, make blood sugar rise significantly, activation of liver cells phosphorylase, acceleration of glycogenolysis, glucagon can also activate lipases, promote fat decomposition, and can enhance fat acid oxidation, so that ketogenesis increase, in addition, the secretion of glucagon may promote insulin and islet somatostatin.

Description:

Glucagon is also known as glucagon or anti insulin or insulin B. It is accompanied by a hormone insulin secretion from pancreatic islet alpha cells of vertebrates. Confrontation and insulin plays a role, increase blood glucose. In 1953, was isolated by precipitation and obtain the crystallization. It is based on the N- terminal histidine as a starting point, C terminal threonine is a single chain peptide terminus of 29 amino acids (molecular weight is about 3500), does not have the S-S bonds in a molecule, at this point, completely different from insulin. The structure of the compound has been synthesized by chemical recent affirmation. The early effect of glucagon process is specific binding exists in the target cell receptors on the cell membrane, the adenylate cyclase activation, ring type AMP as the second messenger activating phosphorylase, promoting glycogenolysis.

Application:

In contrast to the action of insulin, glucagon is a promoting hormone catabolism. Glucagon has very strong promoting glycogenolysis and gluconeogenesis, make the blood glucose increased significantly, 1mol/L hormone can make 3 x 106mol/L glucose from glycogen decomposed rapidly out. Glucagon by cAMP-PK system, the activation of hepatic cells accelerated glycogen phosphorylase, decomposition. Gluconeogenesis is enhanced because hormone accelerate amino acids into liver cells, and activate the enzyme of gluconeogenesis.
Glucagon also activates lipase, promote fat decomposition, and can enhance the oxidation of fatty acid, so that increased ketogenesis. The target organ of glucagon produced the metabolic effects of the liver, liver resection or interruption of hepatic blood flow, these effects disappeared.
In addition, the secretion of glucagon may promote insulin and islet somatostatin. Pharmacological doses of glucagon can make the content of cAMp in myocardial cells increased, myocardial contraction enhancement.



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