Clotrimazole CAS 23593-75-1 Wholesale & Bulk
Clotrimazole is a synthetic pyrrole antifungal drug that has inhibitory effects on a variety of pathogenic fungi. Clotrimazole has broad-spectrum antifungal activity, and has a good antibacterial effect on epidermophyton, trichophyton, aspergillus, pigmented fungus, cryptococcus, and candida, and also has certain antibacterial activities against sporothrix schenckii, Blastomyces dermatitidis, coccidioides immitis, Histoplasma, etc.
Clotrimazole has an inhibitory effect on a variety of pathogenic fungi, and can also have a bactericidal effect when the concentration is high. Clotrimazole inhibits the biosynthesis of sterols such as the fungus ergosterol by interfering with the activity of cytochrome P450; Damage the fungal cell membrane and change its permeability, resulting in the leakage of important substances in the cell; It can also inhibit the biosynthesis of triglycerides and phospholipids of fungi; It inhibits the activity of oxidation and peroxidase, causes excessive accumulation of peroxides in cells, causes degeneration and necrosis of fungal subcellular structures.
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