steroid
Analgesic Antipyretic Phenacetins Pharmaceutical Intermediates
Basic info.
English name: Phenacetin-Acetate
EINECS number: 200-533-0
Molecular formula: C10H13NO2
Molecular Weight: 179.2157
Molecular structure:
Density: 1.099g/cm3
Melting point: 133-138 ºC
Boiling point: 355.1 ° C at 760 mmHg
Flash Point: 168.5 ° C
Water-soluble: 0.076 g / 100 mL
Vapor Pressure: 3.21E-05mmHg at 25 ° C
Assay: 100.58%
Appearance: White crystalline powder
Descriptions:
Using for : reliving wound pains
Section 1st.
It is also called acetophenetidin. Having glossy leaflets or scales-like crystals that have no odor or taste.
Melting point 134 ~ 137. Stable in air, soluble in water, slightly soluble in boiling water, slightly soluble in
ether, soluble in ethanol, chloroform. It is formed through the etherification,reduction and Acetylation
reaction of pchloronitrobenzene. As chloroacetanilide antipyretic and analgesic agent. Suitable for fever,headache, neuralgia and other drugs as a compound agent.
Section 2nd.
Antipyretic effect is stronger than the analgesic effect. Effect of strength is slow and long-lasting as aspirin,
low toxicity. Research shows that: This product and its metabolites acetaminophen have the antipyretic
effect. Because the enzyme inhibitor make phenacetin-Acetate not be converted into paracetamol, still showed
obvious antipyretic effect,thus the antipyretic effect after the product line not converrt to paracetamol.The
mild phenacetin-Acetate analgesic effect usually lasts 3 to 4 hours; and synergistic effect, of alicylic acid
coadministrationmake the analgesic effect enhancement. The main clinical is for small animal antipyretic analgesic. This product is also a component of the APC tablet.
Setion 3rd.
Phenacetin-Acetate is a pain-relieving and fever-reducing drug, widely used from its introduction in 1887 until banned in the US by the FDA in 1983. Its use has declined because of its adverse effects, which include increased risk of certain cancers and kidney damage. It is metabolized into paracetamol, which replaced it in some over-the-counter medications following the ban on phenacetin-Acetate.
Applications:
Analgesic, antipyretic. Component of APC tablets, analgesic mixture also containing aspirin. Phenacetin-Acetate is reasonably anticipated to be a human carcinogen; Analgesic mixtures containing Phenacetin-Acetate are listed as known human carcinogens.
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