Human Progastrin-releasing Peptide (ProGRP)
ProGRPtumormarkeris a recently identified biomarker of small cell lung cancer (SCLC). ProGRPtumor marker is a precursor of a neuropeptide hormone called a gastrin-releasing peptide (GRP), and SCLC cells frequently produce it.
Circulating proGRP levels serve as a reliable marker in patients with SCLC and are the most sensitive marker for discriminating SCLC 16 from benign lung diseases.
ProGRPmarkeris rarely elevating in patients with other malignancies or mild conditions except in patients with renal insufficiency, neuroendocrine tumors of the lung, and medullary carcinoma of the thyroid.
SEKBIOis now offering Mouse anti-human ProGRP mAb, Humanized anti-human ProGRP mAb, and Recombinant human proGRP 31-98 fragment (Prokaryotic expression).
ProGRP Tumor Marker Intro
The progastrin-releasing peptide is a novel small-cell lung cancer marker. PRO GRPtumor marker is a brain-gut hormone. Like a small cell lung cancer marker, PRO GRPmarker has the following characteristics: 1. It has very high specificity for small cell lung cancer; 2. It has a higher positive rate in earlier cases; 3. The blood concentration of healthy people and patients is very different, so Detection reliability is increased.
ProGRP is a specific tumor marker for SCLC, which has advantages over other tumor markers in tumor specificity, progastrin releasing peptideamount, and organ specificity. In addition, the concentration of ProGRP in the blood is less affected by factors such as activity and diet, with slight fluctuation during the day, and hemolysis has little effect on its test results. Therefore, ProGRP is useful for monitoring SCLC patients undergoing treatment and detecting relapse cases.
ProGRP Tumor MarkerFunction
The kidney is one of the main metabolic pathways of progrp assayantibody in the body, and renal insufficiency is an important reason for increasing ProGRP levels. Therefore, the influence of renal dysfunction should be excluded when ProGRP is used to assist in the diagnosis of SCLC. When the patient's creatinine concentration was >140 μmol/L, the progrp testantibody level increased. Therefore, detecting the ProGRP concentration should check the patient's renal function at the same time to exclude the elevated ProGRP concentration caused by chronic renal disease.
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