Polygonum Cuspidatum,Organic Herb IncHigh-quality nutraceut

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Organic Herb Incis a Polygonum Cuspidatumx1e78946n,organic herbs suppliersin one large multi-functional integrated modern enterprise,and devote the high-quality resveratrol manufacturers and first-class service for the masses of customers.



   Organic Herb Inc is specialized in Business services,Medical service,Medical insurance since established in 10 years ago.So far,our company has established its branch companies in major cities throughout the country.Formed in Hunan Province,Changsha City,Changsha County,A301, 1st building, 188# Huanbao Rd.,Changsha 410016, P.R. China as the center, the radiation sales system and service network.Details:
One way of administering Polygonum Cuspidatum extracts resveratrol in humans may be buccal delivery, that is without swallowing, by direct absorption through tissues on the inside of the mouth. When one milligram of resveratrol in 50 ml 50% alcohol/ water solution was retained in the mouth for one minute before swallowing, 37 ng/ml of free resveratrol were measured in plasma two minutes later. This level of unchanged resveratrol in blood can only be achieved with 250 mg of resveratrol taken in a pill form.[15] However, the viability of a buccal delivery method is called into question due to the low aqueous solubility of the molecule. For a drug to be absorbed transmucosally it must be in free-form or dissolved.[16][17] Resveratrol fits the criteria for oral transmucosal dosing, except for this caveat. The low aqueous solubility greatly limits the amount that can be absorbed through the buccal mucosa. Resveratrol that is attempted to be taken buccally was expected to pass through the mucous membrane of the mouth and be absorbed as an oral dose,[18] however, the need to explore buccal delivery in future pharmaceutical formulations was expressed.[17][19] Polygonum Cuspidatum




While 70% of orally administered resveratrol is absorbed its oral bioavailability is approximately 0.5% due to extensive hepatic glucuronidation and sulfation.[20] A formulation of resveratrol in a chewing gum form is now in production, and this would be expected to achieve much higher blood levels than oral formulations. Resveratrol given in a proprietary formulation SRT-501 (3 or 5 g), developed by Sirtris Pharmaceuticals, reached five to eight times higher blood levels. These levels did approach the concentration necessary to exert the effects shown in animal models and in vitro experiments.[21] On May 5, 2010, however, GlaxoSmithKline (GSK) said it had suspended a small clinical trial of SRT501, a proprietary form of resveratrol, due to safety concerns, and terminated the study on December 2, 2010.[22] Polygonum Cuspidatum




In rats, less than 5% of the oral dose was observed as free resveratrol in blood plasma.[23] There is a hypothesis that resveratrol from wine could have higher bioavailability than resveratrol from a pill. Polygonum Cuspidatum




   Adhering to the "dedication, hardworking and thrifty, struggle, innovation" spirit of enterprise, OHIbases on long-term development, technology as the core, market-oriented, and constantly open up new areas, undertaking to provide fast, high-quality ser




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