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Vardenafil (INN) is a PDE5 inhibitor used for treating erectile dysfunction. Vardenafil's indications and contra-indications are the same as with other PDE5 inhibitors; it is closely related in function to Sildenafil citrate (Viagra) and Tadalafil (Cialis). The difference between the Vardenafil molecule and Sildenafil citrate is that a nitrogen atom has different position and the change of Sildenafil's piperazine ring methyl group to an ethyl group. Tadalafil is structurally different from both Sildenafil and Vardenafil. Vardenafil's relatively short effective time is comparable to but somewhat longer than Sildenafil's.
Vardenafil, as with all PDE5 inhibitors, should not be used by men taking nitrate medications, because combining them with Vardenafil might provoke potentially life-threatening hypotension (low blood pressure).
Further, Vardenafil lengthens QT interval. Therefore it should not be taken by men taking other medications that affect the QT interval (such as Amiodarone).

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