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Uses
This medication is used to treat infertility in women. It works by stimulating an increase in the amount of hormones that support the growth and release of a mature egg (ovulation). This medication is not recommended for women whose ovaries no longer make eggs properly (primary pituitary or ovarian failure).

Off-label use
Clomifene citrate has been found very effective in the treatment of secondary male hypogonadism in many cases.This has shown to be a much more attractive option than testosterone replacement therapy (TRT) in many cases because of the reduced cost and convenience of taking a pill as opposed to testosterone injections or gels.Unlike traditional TRT it also does not shrink the testes and as a result can enhance fertility.[citation needed] Traditional TRT has the risk of inducing a chemical gonadectomy, although with monitoring and low-dose hCG as adjunct, this is usually preventable and reversible. Because clomifene citrate has not been FDA approved for use in males it is prescribed off-label. Due to the fact that Clomifene is now a generic medication in most markets, it is unlikely that a drug company would pursue FDA approval for use in men now because of limited profit incentive, mostly due to the relatively small market potential.However, the single isomer of clomifene, enclomiphene under the brand name Androxal, is currently under phase 3 trials for use in men.

Non-clinical uses
Clomifene is used by males (especially steroid users at the end of a cycle) to reduce the physical effects caused by high estrogen levels, such as gynecomastia. The drug binds to estrogen receptors to prevent the hormone from binding and therefore taking effect. It also restores the body's natural production of testosterone.It is included on the World Anti-Doping Agency list of illegal doping agents in sport.










 




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