Polypeptide Hormone Follistatin 315 Antibody Fst-315

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Polypeptide Hormone Follistatin 315 Antibody Fst-315


Basic Info.

Specification: 1mg/vial
Purity: 85%+
Appearance : White powder
Specific Optical Rotation (c=0.5,10% HAc) :-50.0~-60.0°
Water Content(Karl Fischer) : ≤5.0%
Acetate Content(by HPLC) : ≤15.0%
Amino Acid Composition : ±10% of theoretical
Purity (by HPLC) :≥98.0%
Single Impurity(by HPLC) :≤1.0%
Peptide Content(by %N) : ≥80%
Assay(By Anhydrous, Acetic Acid-free ) :95.0~105.0%
Bacterial Endotoxins : ≤5EU/mg
Storage/Stability: Stored at -20 °C if preferred. Storage in frost-free freezers is not recommended.
Note:This product is furnished for LABORATORY RESEARCH USE ONLY. Not for diagnostic or therapeutic use.


Description of Follistatin:

Follistatin is being studied for its role in regulation of muscle growth in mice, as an antagonist to myostatin (also known as GDF-8, a TGF superfamily member) which inhibits excessive muscle growth. Lee & McPherron demonstrated that inhibition of GDF-8, either by genetic elimination (knockout mice) or by increasing the amount of follistatin, resulted in greatly increased muscle mass.In 2009, research with macaque monkeys demonstrated that regulating follistatin via gene therapy also resulted in muscle growth and increases in strength. This research paves the way for human clinical trials, which are hoped to begin in the summer of 2010 on Inclusion body myositis.
A study has also shown that increased levels of follistatin, by leading to increased muscle mass of certain core muscular groups, can increase life expectancy in cases of spinal muscular atrophy (SMA) in animal models.
It is also being investigated for its involvement in polycystic ovary syndrome (PCOS), though there is debate as to its direct role in this infertility disease.


Application:

Follistatin 315 primary function is the binding and bioneutralization of members of the TGF-β superfamily, with a particular focus on activin, a paracrine hormone.

Storage Instruction
Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

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