17 Alpha-Estradiol / Estradiol for Skin Absorption Agent CAS 57-91-0
17 Alpha-Estradiol / Estradiol for Skin Absorption Agent CAS 57-91-0
Basic Info.
Synonyms: Alpha-estradiol; 17A-estradiol
CAS: 57-91-0
EINECS: 200-354-8
Molecular Formula: C18H24O2
Molecular Weight: 272.39
Appearance :hite or off-white crystalline powder
Assay :99%min.
Melting range:216-224 oC
Specific rotation:+52o to +60o
Loss on drying :3.5%MAX
Monor impurity :0.2%MAX
Total impurities:1.0% max
Description:
Estradiol (called α - estradiol or 17α - estradiol) for human breast cancer cells in tissue culture biologically active estrogen. Not part of the 17- and selective estrogen receptor (ER-X) traditional hormone / receptor of the endocrine system, but an important autocrine / paracrine function of the system is part of the growth in the adult brain. In menopause, and neurodegenerative diseases (eg Alzheimer's disease and ischemic stroke) treatment, 17- estradiol may have important implications for hormone replacement therapy thing.
The development of secondary sex characteristics in women is driven by estrogens, to be specific, estradiol. These changes are initiated at the time of puberty, most are enhanced during the reproductive years, and become less pronounced with declining estradiol support after the menopause. Thus, estradiol enhances breast development, and is responsible for changes in the body shape, affecting bones, joints and fat deposition. Fat structure and skin composition are modified by estradiol.
Applications:
This medication is a female hormone. It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected.
Certain estrogen products may also be used by women after menopause to prevent bone loss (osteoporosis). However, there are other medications (such as bisphosphonates including alendronate) that are also effective in preventing bone loss and may be safer. These medications should be considered for use before estrogen treatment.
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