Rabbit Anti-human PTPRE Antibody
Product Name:Rabbit anti-human PTPRE AntibodyCode :CSB-PA019052ESR2HUSize :100μl;50μlUniprot NO. :P23469Storage :Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.Image :Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA019052ESR2HU at dilution 1:100Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA019052ESR2HU at dilution 1:100Western blotAll lanes : PTPRE antibody at 0.6 µg/ml Lane 1 : Mouse kidney tissueLane 2 : Mouse brain tissueSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 80 kDaObserved band size: 80 kDaImmunogen :Recombinant human Receptor-type tyrosine-protein phosphatase epsilon proteinRaised in :RabbitSpecies Reactivity :HumanTested Applications:ELISA,IHC;Recommended dilution:IHC:1:20-1:200Relevance :Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity).Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake.Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca2+.Form :LiquidConjugate :Non-conjugatedStorage Buffer :PBS with 0.02% sodium azide, 50% glycerol, pH7.3.Purification method :Antigen Affinity PurifiedIsotype :IgGClonality :PolyclonalAlias :Receptor-type tyrosine-protein phosphatase epsilon,Protein-tyrosine phosphatase epsilon,R-PTP-epsilon,PTPRESpecies :Human
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