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Enoxaparin Sodium Low Molecular Weight Heparin Sodium Salt

Enoxaparin Sodium is a kind of low molecular weight heparin sodium salt,heparin sodium was benzyl esterized and product was depolymerized under basic condition in the end resulted in Enoxaparin Sodium.Now available information show that majority of the components have a 4-enoxpyranose structure at the end of undergraded chain,15%-25% of the component has a 1,6 anhydride at he end of the degraded chain.

Enoxaparin Sodium is the sodium salt of a depolymerized heparin. It is obtained by alkaline depolymerization of heparin benzyl ester. The starting material, heparin, is obtained exclusively from porcine intestinal mucosa. Enoxaparin Sodium consists of a complex set of oligosaccharides that have not yet been completely characterized.
The weight-average molecular weight of Enoxaparin Sodium is 4,500 Da, the range being between 3,800 and 5,000 Da; about 16 percent have a molecular weight of less than 2,000 Da, the range being between 12.0 and 20.0 percent; about 74 percent have a molecular weight between 2,000 and 8,000 Da, the range being between 68.0 and 82.0 percent. Not more than 18.0 percent have a molecular weight higher than 8,000 Da. When prepared as a solution, the solution is analyzed for clarity and degree of color using a validated method. The degree of sulfation is not less than 1.8 per disaccharide unit. It has a potency of not less than 90 and not more than 125 Anti-Factor Xa International Units (IU) per mg, and not less than 20.0 and not more than 35.0 Anti-Factor IIa IU per mg, calculated on the dried basis. The ratio of anti-factor Xa activity to anti-factor IIa activity is between 3.3 to 5.3.

Storage:Sealed,avoid light and oxygen resistant.

Application:
Enoxaparin sodium is ablood thinner. It used to treat and preventdeep vein thrombosis andpulmonary embolism including duringpregnancy. It is also used in those withacute coronary syndrome andheart attacks.Other uses include insidekidney dialysis machines.



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