Anti-Anxiety Drug

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Founded in 1992, BeijingBeiluPharmaceuticalsCompanyLimitedis mainly engaged in the research & development, production and sales of pharmaceutical products. It is high-tech innovation company with core competence in the Contrast Mediumdomestic. It has around 650 employees with 0.82 Bn/￥ revenue in 2019. Beilu provides complete Contrast Media products suitable for X-Ray and Magnetic Resonance Imaging (MRI), and it is the leading manufacturer in the Contrast Media field in China. It is one of the 1st batches of listed enterprises in GEM of SZSE (Ticker: 300016.SZ) in China.

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How to identify patients with anxiety?
Chief complaints:
Typical somatic symptoms: fatigue, weakness, insomnia, thought slowness, poor appetite

Somatic symptoms A: palpitation, oppression in chest, chest pain, dyspnea, profuse sweating

Somatic symptoms B: headache, dizziness

Somatic symptoms C: abdominal pain, abdominal distension, diarrhea, nausea, dysphagia, weight loss

Somatic symptoms D: dry mouth, constipation, frequent urination, urgent urination, skin flushing or paleness

Inquiry About Anxiety And Depression:

Affective symptoms: tenseness, excessive worries, dysphoria, fear, irritability

Psychological and behavioral symptoms: restlessness, anxiousness and impatience, tremor, body stiffness, sighing respiration, cluttering, over-demanding of comforts and guarantee from doctors, increased alertness and sensitivity

Perform a 90-second questionnaire containing 4 questions for patients with chief complaints of ≥3 somatic symptoms and ≥2 affective symptoms

The 90-second questionnaire containing 4 questions:
1. Do you think you are easily anxious or nervous?
2. Have you been more anxious or nervous recently than usual?
3. Are there any special circumstances or situations that easily make you anxious or nervous?
4. Have you ever had panic attacks, such as sudden intense discomforts or symptoms like palpitation, vertigo, breathlessness or dyspnea?
If 2 or more answers are "Yes", proceed further clinical assessment: in combination with Hospital Anxiety and Depression Scale (HADS)

Questionnaire related to HADS-Anxiety

Item Option Scores
1. I feel tense or distressed Not at all (0)
Sometimes (1)
Most of the time (2)
Almost all the time (3)
2. I get a sort of frightened feeling
as if something awful is about to happen Not at all (0)
A little, but it doesn’t worry me (1)
Yes, but not too badly (2)
Very definitely and quite badly (3)
3. Worrying thoughts go through my mind Only occasionally (0)
Sometimes (1)
Most of the time (2)
Almost all the time (3)
4. I can sit at ease and feel relaxed Definitely (0)
Usually (1)
Not often (2)
Not at all (3)
5. I get a sort of frightened feeling like “butterflies” in the stomach Not at all (0)
Occasionally (1)
Quite often (2)
Very often (3)
6. I feel restless as I have to be on the move Not at all (0)
Not very much (1)
Quite a lot (2)
Very much indeed (3)
7. I get sudden feelings of panic Not at all (0)
Not very often (1)
Quite often (2)
Very much indeed (3)
TOTAL Scores

Questionnaire related to HADS-Depression
Item Option Scores
1. I still enjoy the things I used to enjoy Definitely as much (0)
Not quite so much (1)
Only a little (2)
Hardly at all (3)
2. I can laugh and see the funny side of things As much as I always could (0)
Not quite so much now (1)
Definitely not so much now (2)
Not at all (3)
3. I feel cheerful Most of the time (0)
Sometimes (1)
Not often (2)
Not at all (3)
4. I feel as if I am slowed down Not at all (0)
Sometimes (1)
Often (2)
Nearly all the time (3)
5. I have lost interest in my appearance I take just as much care as ever (0)
I may not take quite as much care (1)
I don’t take as much care as I should (2)
Definitely (3)
6. I look forward with enjoyment to things As much as I ever did (0)
Rather less than I used to (1)
Definitely less than I used to (2)
Hardly at all (3)
7. I can enjoy a good book or radio or TV program Often (0)
Sometimes (1)
Not often (2)
Very seldom (3)
TOTAL Scores

Current Status Of Drug Treatment For Generalized Anxiety Disorders

Generalized anxiety disorder (GAD) is characterized by persistent anxiety and uncontrollable worry about everyday life events for no obvious reason. Most of us feel anxiety now and then, but people with GAD find themselves worrying most of the time, even the worry is often unrealistic or there is little reason to worry. Daily life becomes a constant state of worry, fear and anxiety. The worry in GAD often interferes with a person's daily life. People with GAD may find that they have trouble working, sleeping, socializing, or playing because of worry. At the same time, people with GAD may also experience symptoms such as dry mouth, nausea, feeling tired or weak, trembling, headaches, sweating, trouble concentrating, muscle tension or trouble swallowing etc. As a professional anti-anxiety drugs manufacturer, Beilu Pharma can provide you with a new Chinese patent medicine for treating anxiety.

Up to now, various types of anti anxiety drugs have been shown to be useful for treating GAD, however, compared with some of currently common used western medicines, traditional Chinese medicine is considered a valuable therapeutic option for anxiety disorders and potentially effective technique to reduce the adverse reaction associated with antipsychotic drugs.

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