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Contrast Media

For the purpose of medical imaging, a certain substance is introduced into the human body to change the image contrast of local tissues of the body. This introduced substance is Contrast Media, also known as iv contrast agents. As the first contrast media companiesin China, Beilu Pharma launched the domestic MRI Contrast Media Gadopentetate Dimeglumine Injection in 1992, which broke the foreign products monopoly and filled the domestic gap. As a professional contrast media manufacturer, we could provide a broad portfolio stems Contrast Media across CT/X-ray and MRI modalities, and own the EU standard manufacturing facilities.

Types of Contrast Media in BeiluPharma

MRI CONTRAST MEDIA

Magnetic Resonance Imaging (MRI)Contrast Media is Gadolinium based contrast agent(GBCA). It is an intravenous injection, mainly used to enhance the image quality of internal organs, blood vessels and tissues during MRI examinations. GBCA contains gadolinium, which is connected to each other through carrier molecules to form a chelating agent. According to the different chemical structures, this contrast medium can be divided into two categories: linear and macrocyclic. The linear structure of the imaging agents is easier to release gadolinium ions, and the macrocyclic structure of the contrast materialis more stable and less likely to release gadolinium ions.

Our dedication to your requirements, providing a full range of Contrast Media products

Finished product list

Product name

Characteristic

Specification

1

Gadopentetate Dimeglumine Injection

Injectable solution

469mg/ml: 10ml, 12ml, 15ml, 20ml

2

Gadobutrol Injection

Injectable solution

3

Ferric Ammonium Citrate Effervescent Granules

Oral granules

3g:0.6g(Fe 129mg)

6g:1.2g(Fe 258mg)

4

Iopamidol Injection

Injectable solution

300mgI/ml: 50ml, 100ml

370mgI/ml: 50ml, 100ml

5

Iodixanol Injection

Injectable solution

270mgI/ml: 100ml

320mgI/ml: 50ml, 100ml

6

Iohexol Injection

Injectable solution

300mgI/ml: 20ml,50ml,75ml, 100ml

350mgI/ml: 20ml, 50ml, 100ml

API & Intermediates Product list

Products

CAS NO.

Packings

Classification

1

Iohexol

66108-95-0

25kg

Contrast agent

2

Iodixanol

92339-11-2

25kg

Contrast agent

3

Iopromide

73334-07-3

25kg

Contrast agent

4

Iopamidol

60166-93-0

25kg

Contrast agent

5

Ioversol

87771-40-2

25kg

Contrast agent

6

Gadopentetate Monomeglumine

92923-57-4

25kg

Contrast agent

7

Gadopentetate Dimeglumine

86050-77-3

25kg

Contrast agent

8

Gadobutrol

25kg

Contrast agent

9

Calcobutrol

2kg

Excipients

10

Repaglinide

10kg

Anti-diabetic

11

Diethylenetriaminepentaacetic acid ( Pentaacetic Acid)(DTPA)

67-43-6

Intermediates

12

IOPAMIDOL INTERMEDIATE

(order based) 5-Amino-2,4,6-triiodoisophthalic acid

35453-19-1

25kg

Intermediates

Comparison of physicochemical characteristics of commonly used Contrast Media

Contrast media

(Concentration:mg(I)/ml)

Osmotic pressure

(mOsm/kg water)

Viscosity

(cP,37℃)

Iopamidol 300

616

Ioverol 300

651

Iohexol 300

672

Iobitridol 300

695

6

Iodixanol 320

290

The osmotic pressure of normal people is about 290-300mOsm/kg.

Taking the viscosity of water as 1, when the temperature is 37℃, the relative viscosity of whole blood is 4-5, and the relative viscosity of plasma is 1.6-2.4.

Three factors of renal injury induced by intravascular contrast media: Osmotic pressure, Viscosity and the total iodine. Reduced iodine intake is a feasible strategy to avoid kidney damage.

BeijingBeiluPharmaceuticalsCompanyLimited is a professional anti-anxiety drugs manufacturer, we provide imaging agents, ct cisternography contrastand etc. Want to know iv contrast medication contraindicationsor more? Contact us now.



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