Exenatide Acetate (Exendin-4)

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Product Name

Exenatide Acetate (Exendin-4)

Sequence

H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-
Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-
Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-
Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

Cas No.

141758-74-9

Molecular Formula

C184H282N50O60 S

Molecular Weight

4186.66

Purity (HPLC)

98.0%min.

Appearance

White powder

Single Impurity(HPLC)

1.0%max

Amino Acid Composition

±10% of theoretical

Peptide Content(N%)

≥80.0%

Water Content(Karl Fischer)

≤10.0%

Acetate Content(HPIC)

≤12.0%

MS(ESI)

Consistent

Mass Balance

95.0~105.0%

 

 


Application: 

Exenatide is believed to facilitate glucose control in at least five ways: 
1. Exenatide augments pancreas response and more appropriate amount of insulin that helps lower the rise in blood sugar from eating. 
2. Exenatide also suppresses pancreatic release of glucagon, which prevents hyperglycemia (high blood sugar levels). 
3. Exenatide helps slow down gastric emptying and thus decreases the rate at which meal-derived glucose appears in the bloodstream. 
4. Exenatide has a subtle yet prolonged effect to reduce appetite, promote satiety via hypothalamic receptors. 
5. Exenatide reduces liver fat content. Fat accumulation in the liver or nonalcoholic fatty liver disease (NAFLD) is strongly related with several metabolic disorders.




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