Eptifibatide

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Product Name

Eptifibatide;

Sequence 

Mpr-Har-Gly-Asp-Trp-Pro-Cys-NH2

Cas No.

148031-34-9

Molecular Formula

C35H49N11O9S2

Molecular Weight

832.4

Appearance

White slightly yellwish powder

Specific Rotation[20/D]

-75.0~-95.0°(C=1,1%HAc) 

Amino Acids composition

± 10%

Peptide Purity (By HPLC)

≥98% by area integration

Related Substance (By HPLC)

Total Impurities (%)≤2.0%  Largest Single Impurity (%)≤ 1.0%

Water Content (Karl Fischer)

≤8.0%

Peptide Content(N determination)

≥80%

Acetate Content

≤15%

IR spectrum

in accordance

 

Brief introduction:

Eptifibatide (Integrilin, Millennium Pharmaceuticals, also co-promoted by Schering-Plough/Essex), is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class.[1] Eptifibatide is a cyclic heptapeptide derived from a protein found in the venom of the southeastern pygmy rattlesnake (Sistrurus miliarius barbouri). 

It belongs to the class of the so-called arginin-glycin-aspartat-mimetics and reversibly binds to platelets. Eptifibatide has a short half-life. The drug is the third inhibitor of GPIIb/IIIa that has found broad acceptance after the specific antibody abciximab and the non-peptide tirofiban entered the global market.

Indications

Eptifibatide is used to reduce the risk of acute cardiac ischemic events (death and/or myocardial infarction) in patients with unstable angina or non-ST-segment-elevation (e.g., non-Q-wave) myocardial infarction (i.e., non-ST-segment elevation acute coronary syndromes) both in patients who are to receive non surgery (conservative) medical treatment and those undergoing percutaneous coronary intervention (PCI).




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