Protective Agents (For Liposomes)
Excipients used in solid dosage forms, excipients used in formulation of tablets and excipients of liquid dosage form are very important to reduce or eliminate the damage to liposomes caused by the lyophilization process. Dehydration of liposomes can cause the transition from liquid crystal state to gel state of phospholipids, and rehydration of dried liposomes can also be accompanied by transition from gel state to liquid crystal state, both of which can cause leakage of liposome contents, particle size increasing and the transition from single-chamber to multi-chambers. Therefore, it is very important to select a suitable lyoprotectant to reduce or eliminate the damage to liposomes caused by the lyophilization process. AVT is a reliable supplier of excipients used in semi solid dosage forms and excipients for liquid dosage form.
TYPES OF PROTECTIVE AGENTS (FOR LIPOSOMES)
D(+)-Trehalose Dihydrate (For Injection) CAS NO 6138 23 4
（AVT brand trehalose dihydrate (for injection) is commonly used as lyoprotectants, besides it is also stabilizer and cryoprotectant for lipid nanoparticles and mRNA.
Sucrose (For Injection) CAS No.: 57-50-1
It is injectable grade sucrose of high purity and low endotoxin, which is often used in the pharmactutical industry as a lyoprotectant in nano-formulations and protein biologics.
D(+)-Trehalose Dihydrate (For Injection) (Sterile) CAS No.: 6138-23-4
It is sterile trehalose dihydrate with the characteristics of high glass transition temperature, low hygroscopicity and water retention. It is also heat resistant, acid resistant and extremely stable.
How do Protective Agents (ForLait Liposomes) Work?
The selection of freeze-drying protection agent is an important factor affecting the quality of freeze-drying. The freeze-drying process will lead to the aggregation and fusion of liposomes, accompanied by the leakage of liposome contents, while sucrose can reduce membrane fusion and protect the liposome particles from breaking and leaking drugs during the freeze-drying process. In addition, it can also act as excipients of semi solid dosage forms. If you want more detailed information such as excipients in pharmaceutical formulationsof liquid dosage forms ppt/pdf you can contact AVT.
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