Phospho-L-Tyrosine Disodium Salt
Phospho-L-Tyrosine Disodium Salt in Cell Biology and Molecular Biology Research
Protein Interaction Studies: Used to probe interactions between phosphotyrosine-containing peptides/proteins and SH2 (Src homology 2) domain-containing proteins. For example, it verifies the binding affinity between phosphotyrosine motifs and SH2 domains in signaling adaptors (e.g., Grb2, PI3K), elucidating molecular recognition mechanisms in signal transduction.
Structural Biology: Employed as a ligand in X-ray crystallography or NMR studies to determine the 3D structure of phosphotyrosine-binding proteins (e.g., phosphatases, SH2 domain proteins). This aids in understanding how these proteins recognize and bind phosphorylated substrates at the atomic level.
Functional Validation of Phosphorylation Sites: Used in site-directed mutagenesis experiments to mimic constitutive phosphorylation at specific tyrosine residues in target proteins. By comparing the activity of wild-type vs. phosphomimetic mutants, researchers confirm the functional significance of individual phosphorylation sites (e.g., in enzyme activation or protein localization).
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