Toremifene Citrate
Toremifene Citrate
Synonyms: FC 1157a; Fareston; NK 622; NSC 613680
CAS: 89778-27-8
Molecular Formula: C26H28ClNO·C6H8O7
Molecular Weight: 598.09
Melting Point: 158-164 ºC
Boiling Point: 535.1 ºC at 760 mmHg
Density: 1.045g/cm3
Refractive index: 1,416-1,418
Appearance: White or almost white powder
Function:
Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body. Licensed in the United States under the brand name Fareston, toremifene citrate is FDA-approved for use in advanced (metastatic) breast cancer. It is also being evaluated for prevention of prostate cancer under the brand name Acapodene.
Hormones and Regulation of Endocrine Function of Drug, Anesthetic and Adjuvant, Blood System Agents, Cardiovascular Agents, Urinary System Agents, Respiratory System Agents.
Fareston is a Selective Estrogen Receptor Modulator (SERM), not unlike its more popular cousins Nolvadex and Clomid. Just as we see with Nolvadex, Fareston is used to treat breast cancer in post-menopausal women. It does this by exerting estrogen antagonistic effects in certain tissue, most notably, breast tissue. This is actually the same mechanism of action found in Nolvadex. This is why Nolvadex is often recommended to bodybuilders who are trying to avoid gynocomastia (growth of breast tissue in males). SERMs, in addition, have several other well known effects in men, which are not simply limited to preventing the abnormal growth of breast tissue.
At the hypothalamus and pituitary, estrogen acts in cooperation with the male body's negative feedback loop to send a signal to decrease the secretion of LH, and when LH secretion is lowered, so are natural testosterone levels. SERMs, like Fareston, possibly act as an estrogen antagonist in the hypothalamus and pituitary, in order to increase testosterone production. Thus, although it hasn't been studied to any great degree, it's highly likely that Fareston is capable of increasing testosterone in the same way that Nolvadex it, as it's androgenicity:estrogenicity ratio is 5x that of Nolvadex.
Although anecdotal evidence on this compound is rare, bodybuilders who have already experimented with this stuff seem satisfied. In my estimation, it would seem to be a more potent and safer alternative to Nolvadex, for those who are worried about side effects. I'm also predicting that it may provide a greater increase in LH and therefore testosterone levels, in men when compared to Nolvadex (when an appropriate dose of each is utilized). This makes its use a strong possibility for PCT in the future, when studies on its ability to elevate testosterone is more fully studied and understood.
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