.

Enfuvirtide Acetate (T-20)

Product Name

Enfuvirtide Acetate (T-20)

Sequence

CH3CO-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu
-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-
Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys
-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2

Cas No.

Molecular Formula

C204H301N51O64

Molecular Weight

4492

Purity (HPLC)

98.0%min.

Appearance

White to off-white amorphous solid

Single Impurity (HPLC)

0.5%max

Amino Acid Composition

±10% of theoretical

Peptide Content (N%)

≥80.0%

Water Content (Karl Fischer)

≤8.0%

TrifluoroAcetate Content(HPIC)

≤12.0%

MS (ESI)

Consistent

Mass Balance

95.0~105.0%

2. Description:

Enfuvirtide is an antiretroviral drug used in combination therapy for the treatment of HIV-1/AIDS. It binds to the first heptad-repeat (HR1) in the gp41 subunit of the viral envelope glycoprotein and prevents the conformational changes required for the fusion of viral and cellular membranes. It works by disrupting the HIV-1 molecular machinery at the final stage of fusion with the target cell, preventing uninfected cells from becoming infected.



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