Enfuvirtide Acetate (T-20)
|
Product Name |
Enfuvirtide Acetate (T-20) |
|
Sequence |
CH3CO-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu |
|
Cas No. |
|
|
Molecular Formula |
C204H301N51O64 |
|
Molecular Weight |
4492 |
|
Purity (HPLC) |
98.0%min. |
|
Appearance |
White to off-white amorphous solid |
|
Single Impurity (HPLC) |
0.5%max |
|
Amino Acid Composition |
±10% of theoretical |
|
Peptide Content (N%) |
≥80.0% |
|
Water Content (Karl Fischer) |
≤8.0% |
|
TrifluoroAcetate Content(HPIC) |
≤12.0% |
|
MS (ESI) |
Consistent |
|
Mass Balance |
95.0~105.0% |
2. Description:
Enfuvirtide is an antiretroviral drug used in combination therapy for the treatment of HIV-1/AIDS. It binds to the first heptad-repeat (HR1) in the gp41 subunit of the viral envelope glycoprotein and prevents the conformational changes required for the fusion of viral and cellular membranes. It works by disrupting the HIV-1 molecular machinery at the final stage of fusion with the target cell, preventing uninfected cells from becoming infected.
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