Pharmaceutical Raw Materials Taxus Chinensis Extract Paclitaxel for Anticancer 33069-62-4
Pharmaceutical Raw Materials Taxus Chinensis Extract Paclitaxel for Anticancer 33069-62-4
Basic info:
Paclitaxel
Synonyms: N-BENZYL-BETA-PHENYLISOSERINE ESTER
CAS: 33069-62-4
MF: C47H51NO14
MW: 853.91
EINECS: 205-285-7
Test method: HPLC
Assy(potency): >99%
Residue on ignition: <1%
Appearance: White powder
Usage:
Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is also used for the prevention of restenosis.
Paclitaxel stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division. Together with docetaxel, it forms the drug category of the taxanes.
Product Function:
An antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanc ed forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.
Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it 'taxol'.
When it was developed commercially by Bristol-Myers Squibb (BMS) the generic name was changed to 'paclitaxel' and the BMS compound is sold under the trademark 'TAXOL'. In this formulation, paclitaxel is dissolved in Cremophor EL and ethanol, as a delivery agent. A newer formulation, in which paclitaxel is bound to albumin, is sold under the trademark Abraxane.
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