Tamoxifen Citrate (Nolvadex )
Product Name:Tamoxifen Citrate(Nolvadex )
Synonyms:1-p-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene citrate;(z)-2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylethanamine,citrate(1:;(z)-2-(para-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylethylaminecitrate(;2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethyl-ethanamin(z)-ethanamin2-hydrox;ici46,474;kessar;noltam;tamofen
CAS:54965-24-1
MF:C32H37NO8
MW:563.64
EINECS:259-415-2
MP:140-144 °c
Storage Temp. :2-8°C
Water Solubility:slightly soluble
Chemical Properties:white to off-white powder
Biological Activity:Estrogen receptor antagonist/partial agonist. Selective and potent inhibitor of mammalian sterol isomerase. Neuroprotective in female rats in vivo . Also high affinity agonist at the membrane estrogen receptor GPR30.
Uses:For the treatment of advanced and recurrent breast cancer and ovarian cancer, etc.
Clinical Application:
1). Treatment of breast cancer.
2). Prevention of breast cancer.
3). Anti-tumor and anti-multidrug resistance.
By reducing membrane negotiability and enhancing rigidity of inter-cell binding site, Tamoxifen citrate can reduce concentration and activity of cancer metastasis promoter and various activating enzymes, so as to inhibit or hinder growth and metastasis of cancer cell. In addition, it can promote cells surrounding tumor focus to secrete a negative growth factor - transforming growth factor TGF- G, inhibiting multiply indefinitely of cancer cells; inhibiting oxidative damage of DNA bases which is caused by hydrogen peroxide generated from human neutrophils. So except for breast cancer, it is good for treatment and prevention of other malignant neoplasms, and is used for treatment of brain tumors, liver cancer, prostate cancer, etc. In addition, Tamoxifen citrate can reduce release effect of membrane P170 glycoprotein through reducing membrane negotiability, improving intracellular effective concentration of cytotoxic drug and reducing drug resistance 4).Heart protection.
Send product request
Other supplier products
 |
Testosterone Acetate | Product Name:Testosterone Acetate Synonyms:17-[(1-Oxoacetyl)oxy]androst-4-en-3-one;17-beta-(acetyloxy)androst-4-en-3-one;17beta-Acetoxy-DELTA4-and... |
 |
Nandrolone Phenylpropionate | Product Name: Nandrolone Phenylpropionate Synonyms: Nandrolone Phenpropionate; Nandroloni Phenylpropionas; 17-(1-Oxo-3-Phenylpropoxy)Estr-4-En-3-... |
 |
Letrozole / Femara inhibitors treat breast cancer | Product Name:Letrozole/ Femara Synonyms:4,4'-(1H-1,2,4-triazol-1-ylmethylene) bis-benzonitrile;femara;CGS-20267 CAS: MF:C17H11N5 MW:285.3 Chem... |
 |
Tamoxifen | Tamoxifen Synonyms:(z)-2-(4-(1,2-diphenyl-1-butenyl)phenoxy)phenoxy)-n,n-dimethylethanamine;(z)-2-(para-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimet... |
 |
4-Chlorodehydromethyltestosterone Oral Turinabo for the treatment of male hypogonadism and reduced sperm infertility | Name:4-Chlorodehydromethyltestosterone (Oral Turinabol)Synonyms:4-chloro-17b-hydroxy-17a-methyl-androst-1,4-dien-3-oneCAS: 2446-23-3Molecular Weigh... |
Same products
 |
Copper Polishing Slurry | Seller: Changsha Kona Fine Chemical Co.,Ltd | According to the characteristics of copper material and high requirements of the 3C fabricate, Ko... |
 |
Copper-Covered Ceramic Substrate Polishing Slurry | Seller: Changsha Kona Fine Chemical Co.,Ltd | Copper is a good conductor. Resin substrates, metal substrates and ceramic substrates all need to... |
 |
Cerium Oxide Slurry for Quartz Glass | Seller: Changsha Kona Fine Chemical Co.,Ltd | As a cerium oxide polishing powder manufacturer, Kona provides polishing slurry with cerium oxide... |
 |
A-Plane Sapphire Colloidal Silica | Seller: Changsha Kona Fine Chemical Co.,Ltd | Kona series Sapphire Polishing Slurry developed for kinds of Sapphire products, such as sapphire ... |
 |
Metal Mirror Polishing Slurry | Seller: Changsha Kona Fine Chemical Co.,Ltd | Kona Metal Mirror Finish Polishing Slurry is an advanced blend of abrasive particles and high-gra... |
