.

99% Purity Cancer Treatment Steroids Formestane for Breast CAS 566-48-3


99% Purity Cancer Treatment Steroids Formestane for Breast CAS 566-48-3



Basic Info.

Product name: Formestane
Other name: Lentaron; FORMESTAQNE; Hydroxyandrostenedione
CAS Registry Number: 566-48-3
Assay: 98%Packing: 1kg/aluminum foil bag
Molecular Formula: C19H26O3
Molecular Weight: 302.41
Appearance: White crystalline powder


Product Description:

Formestane was the first selective, type I, steroidal aromatase inhibitor used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women. Formestane suppresses estrogen production from anabolic steroids or prohormones. It also acts as a prohormone to 4-hydroxytestosterone, an active steroid which displays weak androgenic activity in addition to acting as a mild aromatase inhibitor. It is listed as a prohibited substance by the World Anti-Doping Agency for use in athletes.

Formestane has poor oral bioavailability, and thus must be administered forthnightly (bi-weekly) by intramuscular injection. Some clinical data has suggested that the clinically recommended dose of 250mg was too low. With the discovery of newer, non-steroidal and steroidal, aromatase inhibitors which were orally active and less expensive than formestane, formestane lost popularity.

Currently, formestane (categorized as an anti-estrogenic agent) is prohibited from use in sports in accordance to the regulations of the World Anti-Doping Agency. It is not US FDA approved, and the intramuscular injection form of formestane (Lentaron) which was approved in Europe has been withdrawn.

Formestane (Lentaron) is a type I, steroidal aromatase inhibitor. It is used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women. It is available as an intramuscular depot injection.

Formestane is often used to suppress estrogen production from anabolic steroids or prohormones. It also acts as a prohormone to 4-hydroxytestosteron, an active steroid which displays weak androgenic activity in addition to acting as a mild aromatase inhibitor.

Formestane has poor oral bioavailability and as such is no longer popular as many orally active aromatase inhibitors have been identified.



Applications:

Formestane is a second generation, irreversible, steroidal aromatase inhibitor. It inhibits the aromatase enzyme responsible for converting androgens to estrogens, thereby preventing estrogen production. Breast cancer may be estrogen sensitive or insensitive. A majority of breast cancers are estrogen sensitive. Estrogen sensitive breast cancer cells depend on estrogen for viability. Thus removal of estrogen from the body can be an effective treatment for hormone sensitive breast cancers. Formestane has been targeted specifically for the treatment of postmenopausal women. Unlike premenopausal women who produce most estrogen in the ovaries, postmenopausal women produce most estrogen in peripheral tissues with the help of the aromatase enzyme. Formestane, an aromatase inhibitor, can thus help to decrease the local production of estrogen by blocking the aromatase enzyme in peripheral tissues (ie. Adispose tissue of the breast) to treat hormone sensitive breast cancer.



Send product request

To: Guangzhou Kafen Biotech Co., Ltd.
Your E-mail:
Message text:


Send to other suppliers

Other supplier products

High Purity Male Sex Hormones Vardenafil HCL / Levitra for Sex Enhancer Powder
High Purity Male Sex Hormones Vardenafil HCL / Levitra for Sex Enhancer Powder High Purity Male Sex Hormones Vardenafil HCL / Levitra for Sex Enhancer Powder Basic Info: CAS No: MF: C23H33ClN6O4S MW: 525.06 Purity: 99% Hal...
CAS 5630-53-5 Anti Aging Estrogen Steroids Tibolone Livial for Female Hormones Medicines
CAS 5630-53-5 Anti Aging Estrogen Steroids Tibolone Livial for Female Hormones Medicines CAS 5630-53-5 Anti Aging Estrogen Steroids Tibolone Livial for Female Hormones Medicines Basic Info. Product name: Tibolone Alias: LIVIELLA; LIV...
Bodybuilding Peptides Human Growth Hormones Fragment HGH 176-191
Bodybuilding Peptides Human Growth Hormones Fragment HGH 176-191 Bodybuilding Peptides Human Growth Hormones Fragment HGH 176-191 Basic Info. Unit Size : 2 mg/vial Unit Quantity : 1 Vial Synonyms : HGH FRAG 1...
96-48-0 GBL Intermediate GBL Wheel Cleaner Gamma Butyrolactone
96-48-0 GBL Intermediate GBL Wheel Cleaner Gamma Butyrolactone 96-48-0 GBL Intermediate GBL Wheel Cleaner Gamma Butyrolactone Basic Info. Gamma-Butyrolactone Alias: Gamma Butyrolactone, 1, 4- Butyrolactone, &ga...
CAS 2322-77-2 Androgenic Steroid Intermediate Methoxydienone Max LMG Raw Hormone Powder
CAS 2322-77-2 Androgenic Steroid Intermediate Methoxydienone Max LMG Raw Hormone Powder CAS 2322-77-2 Androgenic Steroid Intermediate Methoxydienone Max LMG Raw Hormone Powder Basic Info. CAS: 2322-77-2 EINECS: 219-034-4 MF: C20H28O...
All supplier products

Same products

Chinese factory Topiramate/Topiramato powder with USP/GMP standard
Chinese factory Topiramate/Topiramato powder with USP/GMP standard Seller: 778190 English name:Topiramate(Topiramato) CAS Number: 97240-79-4 Molecular formula: C12H21NO8S Molecula...
Chinese factory Orthoboric acid powder with USP/GMP standard
Chinese factory Orthoboric acid powder with USP/GMP standard Seller: 778190 English name:Orthoboric acid(Ácido ortobórico) CAS Number: 10043-35-3 Molecular for...
Ourope market 99% pure Tryptamine powder with USP/BP standard
Ourope market 99% pure Tryptamine powder with USP/BP standard Seller: 778190 English name:Tryptamine(Triptamina) CAS Number: 61-54-1 Molecular formula: C10H12N2 Molecular wei...
99% pure Diltiazem powder with USP/BP standard
99% pure Diltiazem powder with USP/BP standard Seller: 778190 English name:Diltiazem CAS Number: 42399-41-7 Molecular formula: C22H26N2O4S Molecular weight: 41...
100% customs clearance oxiracetam powder with USP/GMP standard
100% customs clearance oxiracetam powder with USP/GMP standard Seller: 778190 English name:oxiracetam CAS Number: 62613-82-5 Molecular formula: C6H10N2O3 Molecular weight: 158...