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T3 is one of the two biologically active Thyroid Hormones, the other being T4. T3 is seen as more potent although less prominent in the body, and T4 can act as a reservoir of potential T3, to be converted into the more potent form through a class of enzymes known as deiodinases.
T3 VS T4
1.Against Each other
The fat loss effects of T3 supplementation appear to be more effective than T4 supplementation at weight loss, although studied in hypothyroidics and dosed in accordance to TSH levels, at an average dose of 0.57mcg/kg bodyweight
2.In conjunction with each other
The combination of T3/T4 (in which 50mcg of T4 was exchanged for 10mcg T3) in comparison to straight T4 supplementation had no significant differences in term of subjective well-being and treatment of hypothyroidism. and similar lack of results seen with a higher dose substitutionand lower doses.These results are in contrast to an earlier study which showed benefit substituting 50mcg T4 for 12.5mcg T3 which appears to stand alone.
Effects on Fat Metabolism
T3 (or more specifically, thyroid hormones in general) are investigated for their interactions with fat mass since, in survey research, thyroid activity may be related to fat mass and BMI.
Effects on Muscle Tissue
n obese subjects, a reduction in urinary nitrogen has been reported with T3 supplementation, and was additive to fasting's reduction in urinary nitrogen; suggesting a muscle preserving effect.[21] These results have been replicated a short-term metabolic ward study at 100mcg daily, in four divided dosages
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