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Nobiletin

Xi’AN LESEN BIO-TECHNOLOGY CO.,LTD specializes in the ten years of plant extracts and export trade, to provide customers with high-quality, organic, natural, good price of various plant extracts, fruit and vegetable powder, as well as cosmetics, chemical raw materials.Nobiletin is a citrus flavonoids. It has the typical flavonoid structure and contains 6 methoxyl groups, one more than tangeretin. This high level of methoxylation increases the hydrophobic character of tangeretin. Pure nobiletin has the appearance of colorless needles and has a bitter taste. Nobiletin seems to be a very noble phytochemical with many potential health benefits. The most studied properties of nobiletin are its anti-inflammatory and anti-cancer activities. Nobiletin also helps to lower cholesterol levels and some studies indicate that it may improve impaired memory loss and treat acne.  Nobiletin acts directly as an antioxidant but also interferes with biological inflammatory processes. It inhibits the expression of genes involved in inflammation by blocking the binding of NF-kappaB with DNA. One study showed that nobiletin reduced airway inflammation of asthmatic rats. Treatment of skin cells with nobiletin also reduced inflammation caused by ultraviolet-B radiation.Prodcut name: NobiletinLatin Name: Citrus aurantium L.Specification:  5%-98%Appearance: Light yellow powderMesh size: 80 MeshUsed Part: PeelGrade: Food & PharmaceuticalBrand Name: LS-HerbTest Method: HPLC Analysis Sheet:AnalysisSpecificationResultIdentificationPositive ReactionCompliesAssay (Nobiletin)20% Min20.40%AppearanceLight brown-yellow powderCompliesOdorCharacteristicCharacteristicLoss on drying5.0% Max10.89%Ash Content5.0% Max0.15%Heavy metals 10ppm MaxCompliesArsenic1ppm MaxCompliesMercury0.1ppm MaxCompliesCadmium1ppm MaxCompliesLead3ppm MaxCompliesResidual SolventsEur. Pharm2000CompliesMicrobiologyTotal plate count 1000cfu/g MaxCompliesYeast & Mould100cfu/g MaxCompliesE. Coli  NegativeNegativeSalmonellaNegativeNegativeFunction:1. Antioxidant, anti-inflammatory, hypolipidemic, vasoprotective and anticarcinogenic and cholesterol lowering actions. 2. Inhibit following enzymes: Phospholipase A2, lipoxygenase, HMG-CoA reductase and cyclo-oxygenase. 3. Improve the health of capillaries by reducing the capillary permeability. 4. Reduce hay fever and other allergic conditions by inhibiting the release of histamine from mast cells. The possible anti-cancer activity of hesperidin could be explained by the inhibition of polyamine synthesis.Applications:1. As Food and beverage ingredients.2. As Healthy Products ingredients.3. As Nutrition Supplements ingredients.4. As Pharmaceutical Industry & General Drugs ingredients.5. As a health food and cosmetic ingredients.


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