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CAS NO.Product Name AG-120; RG120SynonymsIvosidenibFormulaC28H22ClF3N6O3Molecular Weight582.14Spec / Purity98%minSupply Capacity Details Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells.
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