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XL-518 CAS:

If you are going to consult the information about from one of the leading manufacturers and suppliers in China, Biopharmaleader Co.,Ltd is always at your service.Product Information CAS NO. Product NameCobimetinibSynonymsXL-518;GDC-0973FormulaC21H21F3IN3O2Molecular Weight531.31Spec / Purity98%minSupply CapacityDetailsCobimetinib (GDC-0973, XL-518) is a MEK inhibitor being . It is being studied in combination with BRAF inhibitors to treat several cancers. Early data showed that administration of Cobimetinib in combination with the BRAF inhibitor vemurafenib increased progression-free survival in melanoma patients with a BRAF V600 mutation by 3.7 months compared to vemurafenib alone. Phase 3 clinical trials are ongoing and expected to complete by 2017. After good results in 2014 the combination has been submitted to EC and FDA for marketing approval. 


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