99.5% Pharmaceutical Grade Meldonium Mildronate CAS 76144-81-5
99.5% Pharmaceutical Grade Meldonium Mildronate CAS 76144-81-5
1.Quick Details:
Product Name:Meldonium
Alias:Mildronate
MF:C6H14N2O2
MW:146.18756
CAS:76144-81-5
Grade:Pharmaceuticals
Purity:99.5%
Storage:Keep it dry
2.Product Description:
Meldonium,trade-named as Mildronate among others, is a limited-market pharmaceutical, developed in 1970 by Ivars Kalviņš, Latvian Institute of Organic Synthesis (USSR), and manufactured primarily by Grindeks of Latvia and several generic manufacturers. It is distributed in Eastern European countries as an anti-ischemia medication.Since 1 January 2016, it has been on the World Anti-Doping Agency (WADA) list of substances banned from use by athletes.However, there are debates over its use as an athletic performance enhancer. Some athletes are known to have been using it before it was banned. It is currently unscheduled in the US.
The chemical name of meldonium is 3-(2,2,2-trimethylhydraziniumyl) propionate.It is a structural analogue of γ-butyrobetaine, with an amino groupreplacing the C-4 methylene of γ-butyrobetaine.[citation needed] γ-Butyrobetaine is a precursor in the biosynthesis of carnitine.[better source needed][needs update] It has a molecular weight of 146.188. It is available as a white crystalline powder, as well as a capsule sold by Grindeks. The melting point is anywhere between 85-90 degrees Celsius
3.Product Application:
Meldonium may be used to treat coronary artery disease.These heart problems may sometimes lead to ischemia, a condition where too little blood flows to the organs in the body, especially the heart. Because this drug is thought to expand the arteries, it helps to increase the blood flow as well as increase the flow of oxygen throughout the body.Meldonium has also been found to induce anticonvulsant and antihypnotic effects involving alpha 2-adrenergic receptors as well as nitric oxide-dependent mechanisms. This, in summary, shows that meldonium given in acute doses could be beneficial for the treatment of seizures and alcohol intoxication.It may also have some effect on decreasing the severity of withdrawal symptoms caused by the cessation of chronic alcohol use.
4.Product Function:
Meldonium is believed to work through its ability to increase the size of blood vessels and therefore improve blood flow.Although initial reports suggested meldonium is a non-competitive and non-hydroxylatable analogue of gamma-butyrobetaine;[9][non-primary source needed] further studies have identified that meldonium is a substrate for gamma-butyrobetaine dioxygenase. X-ray crystallographic and in vitro biochemical studies suggest that meldonium binds to the substrate pocket of γ-butyrobetaine hydroxylase and acts as an alternative substrate ,and therefore a competitive inhibitor.[non-primary source needed] Normally, this enzyme's action on its substrates γ-butyrobetaine and 2-oxoglutarate gives, in the presence of the further substrate oxygen, the products L-carnitine, succinate, and carbon dioxide; in the presence of this alternate substrate, the reaction yields malonic acid semialdehyde, formaldehyde (akin to the action of histone demethylases), dimethylamine, and (1-methylimidazolidin-4-yl)acetic acid, "an unexpected product with an additional carbon-carbon bond resulting from N-demethylation coupled to oxidative rearrangement, likely via an unusual radical mechanism
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Store in cool and dry area and keep away from direct sunlight.oC
Shelf life
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