Pharma grade hydroxypropyl beta cyclodextrin supplement with USP EP standard in Sigma

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Hydroxypropyl beta cyclodextrin;HPBCD; HPCD

CAS No.: 94035-02-6

M.F.:C42.(H)70-n.O35.(C3H7)n

M.W.:1431-1806

Standards:USP40,EP9.0,BP2015,CP2015

Grade: Oral or Injection

Storage:Preserved in well-closed containers

Shelf life:2 years when properly stored.

Package:1kg/bag,25kg/drum.Or it's at youroption .

Introduction :

Hydroxypropyl-β-cyclodextrin (HP-β-CD) is the hydroxyalkylated derivatives of β- cyclodextrin (β-CD). HP-β-CD is non-toxic and has no side effect, and it can significantly improve the solubility of insoluble drugs to dissolve insoluble or poorly water-soluble drugs due to its structural particularity. Therefore, it can effectively increase bioavailability of drugs; it can also improve drug quality and variety of dosage forms, thereby being applied in development and production of new drugs. Globally, in-depth studies of the properties, preparation technology, stability, pharmacology, toxicology, teratogenic, mutagenic, carcinogenic, hemolysis, irritation and other aspects of HP-β-CD have already been performed; the safety of this drug has been evaluated accurately. Among all the derivatives of β-CD, HP-β-CD is considered as a type of pharmaceutical excipients with most complete research data and highest medicinal value, and it has been studied in-width and in-depth mostly.

Applications:

1:Medical use of hydroxypropyl β-cyclodextrin

Due to the low surface activity, low hemolytic activity and non-irritation to muscles, Hydroxypropyl β-cyclodextrin is considered an ideal pharmaceutical excipient and solubilizer in injections in pharmaceutical industry. It works to solubilize water-insoluble drugs, enhance drug stability, improve drug bio-availability (improve efficacy or lower dosage of drugs), moderate and control drug release, and can also help to diminish the toxicity and side effects of drugs. Further, Hydroxypropyl β-cyclodextrin can be applied as a drug carrier in oral medications, injections, mucosal drug delivery system, transdermal drug delivery system, and targeted lipophilic drugs. Also, it is suitable as a protectant and stabilizer for proteins.

2:Household chemicals

As a stabilizer, emulsifier and scent masking agent, hydroxypropyl β-cyclodextrin can minimize the irritation to skin and mucous membranes resulting from the organic molecules in cosmetics. Additionally, it enhances the stability of active ingredients, protects nutrients against vaporization and oxidation, solubilizes insoluble fragrance and sustains the release of the fragrance to keep it long-lasting.

3: Food industry

Hydroxypropyl β-cyclodextrin can improve the stability and long-acting efficacy of food nutrients while covering or counteracting the unpleasant smells and tastes. By using hydroxypropyl β-cyclodextrin, the manufacturing process and product quality can be improved and the shelf period can be prolonged.

4. Other sectors

Hydroxypropyl β-cyclodextrin has been widely used in many sectors including coating and painting products, tobacco products, pesticide excipients, plant growth regulators for agricultural use, paper industry, textile industry, et al. As people are gaining great awareness of hydroxypropyl β-cyclodextrin, it shows great promise and is used in more and more fields.

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