Chenodeoxycholic Acid (CDCA）CAS:474-25-9

Product Name:

Chenodeoxycholic acid

Synonyms:

URSODEOXYCHOLOC ACID;3,7-dihydroxy-,(3-alpha,5-beta,7-alpha)-cholan-24-oicaci;3,7-dihydroxy-,

(3alpha,5beta,7alpha)-cholan-24-oicaci;3,7-Dihydroxy-5-Cholanicacid;

3-alpha,7-alpha-dihydroxy-5-beta-cholan-24-oicaci;3-alpha,7-alpha-dihydroxy-5-beta-cholan-24-oicacid;

3-alpha,7-alpha-dihydroxycholanicacid;3-alpha,7-alpha-dihydroxycholansaeure

CAS:

href="" 474-25-9

MF:

C24H40O4

MW:

EINECS:

207-481-8

Product Categories:

Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Intracellular receptor

Mol File:

474-25-9.mol

Chenodeoxycholic acid Chemical Properties

mp

165-167°C(lit.)

alpha

12 º (c=1, CHCl3)

storage temp.

Refrigerator

solubility

PRACTICALLY INSOLUBLE

Water Solubility

PRACTICALLY INSOLUBLE

Merck

13,2062

CAS DataBase Reference

474-25-9(CAS DataBase Reference)

EPA Substance Registry System

Cholan-24-oic acid, 3,7-dihydroxy-, (3.alpha.,5.beta.,7.alpha.)- (474-25-9)

chenodeoxycholic acid:synthesis methodand Chemical property

This product is extracted from the bile of pigs, chickens, ducks, geese, white or light yellow crystalline powder, bitter taste,.Mp141-142 C, soluble in ethanol, chloroform and acetic acid, almost insoluble in water.

This product can make the cholesterol synthesis and secretion is reduced, total cholesterol in bile excretion decreased, thereby improving the dissolving capacity of cholesterol in bile, promote has stone cholesterol dissociation to dissolve stone effect. A high concentration in the gallbladder after oral administration of the goods and repeatedly enterohepatic circulation. This product in the gut easily decomposing bacteria, produce liver toxicity of the metabolites.

Use

Cholelitholytic drug. For prevention and treatment of cholesterol gallstones and high fat blood, bile pigment stones and mixed stones also certain effect. For mild symptoms and the good function of the gallbladder, biliary obstruction patients better. Long term use of mild diarrhea, a small number of patients can have itching, dizziness, nausea and abdominal distention, individual patient can be induced biliary colic and transient transaminase elevations. Pregnant women, women of childbearing age, pancreatitis, liver cirrhosis, duodenal and gastric ulcer, hepatitis and biliary obstruction disable.

Advantage

This product is one of the world largest amount drugs which use for treatment of gallstones,meantime it is a raw material for synthesis of Ursodeoxycholic acid(UDCA) and other steroids