L-Methionine in Pharmaceutical and Medical Applications
In pharmaceuticals, L-Methionine is used for therapeutic purposes and as a pharmaceutical excipient, leveraging its metabolic and antioxidant properties: Treatment of Liver Diseases: Used as an adjuvant therapy for non-alcoholic fatty liver disease (NAFLD), liver cirrhosis, and drug-induced liver injury. It promotes liver detoxification by increasing glutathione (GSH) levels, enhances fatty acid oxidation, and reduces liver fat accumulation. It is also used to protect the liver from toxins (e.g., alcohol metabolites, heavy metals). Management of Methionine Deficiency: Prescribed for patients with malnutrition (e.g., due to gastrointestinal disorders, cancer cachexia) or inherited metabolic disorders (e.g., cystathionine β-synthase deficiency) that cause methionine deficiency. Supplementation helps correct amino acid imbalances and prevent related complications (e.g., muscle wasting, neurological disorders). Antioxidant and Anti-Inflammatory Therapies: Used in supplements for patients with oxidative stress-related conditions (e.g., neurodegenerative diseases, cardiovascular disorders) to enhance GSH synthesis and reduce reactive oxygen species (ROS) damage. It also supports immune function in immunocompromised patients (e.g., post-surgery, HIV/AIDS). Pharmaceutical Excipient: Occasionally used as a stabilizer or solubilizer in drug formulations, improving the stability and bioavailability of active pharmaceutical ingredients (APIs).
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