3-Bromocinnamic acid

Производитель:

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Synonyms:RARECHEM BK HC T307; TRANS-3-BROMOCINNAMIC ACID; M-BROMOCINNAMIC ACID; M-BROMOPHENYLACRYLIC ACID;BROMOCINNAMIC ACID,3-;3-BROMOCINNAMIC ACID; AKOS BBS-00006566; AKOS B004044

CAS NO.:32862-97-8

Formula:C9H7BrO2

 

Molecular weight: 227.05

EINECS NO.:251-267-7

Melting point: 177-179 °C

Appearance: Colorless crystal

Vapor pressure: 0.0±0.8 mmHg at 25°C

Refractive index: 1.648

Storage: Shading, confined preservation, dry, ensure good ventilation or exhaust in the workshop

Stability: Stable under normal temperature and pressure

Key words: 3-Bromocinnamic acid, spices, essence, Synthetic essence,

 

General description

3-Bromocinnamic acid is the metabolite of cinromide (3-bromo-N-ethylcinnamamide) and can be analysed in plasma by high-performance liquid chromatographic method.

Simultaneous determination of the anticonvulsants, cinromide (3-bromo-n-ethylcinnamamide), 3-bromocinnamamide, and carbamazepine in plasma by high-performance liquid chromatography.

3-Bromocinnamic acid is used as organic synthesis of raw materials, fine chemicals, pharmaceutical intermediates.

 

Abstract

A high-performance liquid chromatographic method is described for monitoring plasma concentrations of cinromide (3-bromo-N-ethylcinnamamide) and its de-ethylated metabolite. Carbamazepine levels can be easily measured by the same technique. The N-isopropyl analogue of cinromide is used as internal standard, and all compounds are easily separated on a reversed-phase column operated at 55 degrees with a small-diameter pre-column maintained at the same temperature. The extraction is rapid and generally applicable to plasma and urine samples that are to be analyzed by reversed-phase chromatography. Short- and long-term reproducibility studies show less than 4% relative standard deviation for replicate determinations for all drugs. Limits of quantitation are 10-20 ng/ml with an internal standard concentration of 3 micrograms/ml. Another metabolite of cinromide, 3-bromocinnamic acid, which may have some anticonvulsant effect, can be analyzed simultaneously by buffering the mobile phase and adding an ion-pairing reagent. Storage: Pay attention to the source of fire, especially to avoid sunlight, and store in a cool place.

Specifications

Item

REQUIREMENT

RESULT

Assay

≥99%

  1. 20 %

Description

Colorless crystal

White or slightlyyellow crystal

Melting point

177-179 °C

178°C

Rotation ratio

  1. 6317-1.6482
  2. 6471
 



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