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Purity 99% Progestin Steroid Powder Medroxyprogesterone Acetate

1.Basic Info

Product name Medroxyprogesterone Acetate
Synonyms Medroxyprogesterone 17-acetate;hydroxymethylprogesterone acetate
CAS Registry Number 71-58-9
M.F. C24H34O4
M.W. 386.52
Assays 99%
Appearance White or white crystalline powder






2.Description:

Medroxyprogesterone acetate (INN, USAN, BAN), also known as 17α-hydroxy-6α-methylprogesterone acetate, and commonly abbreviated as MPA, is asteroidal progestin, asynthetic variant of the steroid hormone progesterone. It is used as acontraceptive, in hormone replacement therapy and for the treatment of endometriosis as well as several other indications.
MPA is amore potent derivative of its parent compound medroxyprogesterone (MP). While medroxyprogesterone is sometimes used as asynonym for medroxyprogesterone acetate,what is almost always being referred to is MPA and not MP.It is on the World Health Organization's List of Essential Medicines, alist of the most important medication needed in abasic health system.




3.Application:

In females, the most common use of MPA is as an oral or depot-injected contraceptive and also as the progestin component of menopausal hormone replacement therapy to prevent endometrial hyperplasia and cancer. MPA is also used as atreatment for endometriosis, dysmenorrhea, and amenorrhea.MPA, along with other progestins were developed to allow the hormones to be taken orally, as progesterone (the hormone made by the human body) could not be taken orally before the process of micronization was developed.
In males, MPA has been used to control inappropriate sexual behavior to chemically castrate convicted sex offenders.
MPA is an extremely effective contraceptive when used with relatively high doses to prevent ovulation. It has also been used to treat benign prostatic hyperplasia, as apalliative appetite stimulant for cancer patients, and at high doses (800 mg per day) to treat hormone-dependent cancers of primarily the breast, but also other types.
Though not used as atreatment for epilepsy, MPA reduces the frequency of seizures and does not interact with anti-epileptic medications. MPA does not interfere with blood clotting and appears to improve blood parameters for women withsickle cell anemia. Similarly, MPA does not appear to affect liver metabolism, and may improve primary biliary cirrhosisand chronic active hepatitis. Women taking MPA may experience spotting shortly after starting the medication but is not usually serious enough to require medical intervention. With longer use amenorrhoea can occur as can irregular menstruation which is amajor source of dissatisfaction, though both can result in improvements with iron deficiency and risk of pelvic inflammatory disease and often do not result in discontinuing the medication.[9] MPA is also prescribed in combination with an estrogen to prevent endometrial hyperplasia in post-menopausal women who are undergoing hormone replacement therapy.
MPA has also been prescribed in hormone replacement therapy for male-to-female transgender individuals due to itsantiandrogen and progestogen effects.




4.Side effects

In females, the most common adverse effects are acne, changes in menstrual flow, drowsiness, and can cause birth defects if taken by pregnant women. Other common side effects include breast tenderness, increased facial hair, decreased scalp hair, difficulty falling or remaining asleep, stomach pain, and weight loss or gain.
The Women's Health Initiative investigated the use of MPA and conjugated equine estrogens compared to placebo. The study was prematurely terminated when previously unexpected risks were discovered, specifically the finding that though the all-cause mortality was not affected by the hormone therapy, the benefits of the hormone replacement therapy (reduced risk of hip fracture, colorectal and endometrial cancer and all other causes of death) were offset by increased risk of coronary heart disease, breast cancer, strokes and pulmonary embolism.However, the study focused on MPA only and extrapolated the benefits versus risks to all synthetic progesterones-a conclusion that has been challenged by several researchers as unjustified and leading to unnecessary avoidance of HRT for many women as synthetic progesterones are not alike.




5.COA:

TESTITEMS SPECIFICATION RESULTS
Description WhiteCrystallinePowder WhitePowder
Identification Positive Positive
Assay(byHPLC) 98.0~102.0% 98.64%
Absorbance(E1cm) 465~495 482.5
MeltingPoint 191~195 193.5~195.0
LossOnDrying 0.5%max 0.19%
SpecificRotation +288~+298 +290.2
ResidueOnIgnition 0.1%max 0.03%
RelatedSubstances Total:1.5%max <1.3%
ResidueSolvents 0.2%max 0.10%
HeavyMetals 20PPmmax <10PPm
Conclusion Thespecificationconformwithenterprisestandard.





6.Payment &Delivery Information :

Payment Method:Western Union,Money Gram,T/T ,Bitcoin
Minimum Order:10-100 grams.our min packing of each powder is 10g or 100g, but some expensivepowder can be bought at several grams .As for oil steroids ,our MOQ is 50ml .
Professional Delivery :By courier (EMS, DHL, Fedex, UPS,TNT) is preferable ,bulk order can be negotiable.
Dispatch time:As for powders ,within 24h once the receipt of payment .As for oil liquid ,within 48h once the receipt of payment .
Tracking number :Can be offered to you within 48h for powders .Could be provided to you within 72h for oil liquid.
Delivery time:4~6 working days after the receipt of payment for powders by courier ,5~7 working days after the receipt of payment for oil liquid by courier .
Discreetly Packing: Safe and professional disguised package can be guaranteed .We also have completely re-send policy to some areas .As for most countries ,we will resend your parcel if your parcel fail to pass customs .
Adequate Stock:Most of powders are in stock .We export over 1000 kilograms of steroid powder per month .
High Delivery Rate:Our goods packing will not contain any hormone information and can be sent out from different areas of china .At present ,the goods customs clearance rate we send to United states and Europe is 99%,As for Canada ,Brazil of quite high buckle close rate area ,we also have anew way to pass the customs .



7.How To Order Your Products That You Needs?

1.First: Please let me know the items you are looking for, quantity, and the destination country
2.Second: You confirm all details, and offer us purchasing order.
3.Third: We send the detail price of our product and offer the suitable shipping method for reference.
4.Forth: You confirm the order and pay money 100% in advance and send us the detail address.
5.Fifth: We arrange the shipment according to your requirements.
6.Sixth: We offer after-sales service after you receive parcel;



8.Customer feedback :

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---Aston

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9.Hot selling market :

United State(USA) ,United Kingdom(UK) ,Australia ,Canada ,Spain ,France ,Germany ,Russia ,Brasil(Brazil) ,Ukraine ,South Africa ,Norway ,Poland ,Netherlands(Holland) ,Slovakia ,Georgia ,New Zealand ,Sweden etc.



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