Reducing Fat Mass Chemicals Sr9011 CAS Pharmaceutical Grade

• 

Reducing Fat Mass Chemicals Sr9011 CAS Pharmaceutical Grade Basic Info: Cas No Synonyms 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-1-carboxamide Formula C23H31ClN4O3S Molucelar weight 479.03524 Product Description: SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates. SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols. Usage levels of 5% to 10% by weight are recommended. SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV ERB α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases. Application: In vitro: SR9011 was used at 5-10 μM concentration in vitro and in cellular assays. In vivo: IP administration of SR9011 was used at 100 mg/kg once or twice per day for 12-30 days in different mouse models.

Другие товары поставщика

	Anabolic Steroid Powder Androstenolone DHEA Dehydroepiandrosterone For Muscle Strength	Anabolic Steroid Powder Androstenolone DHEA Dehydroepiandrosterone For Muscle Strength Basic Info. Product name: Dehydroepiandrosterone Other n...
	Local Anesthetic Raw MateriLocal Anesthetic Raw Materials Procaine in White Crystalline Powderals Procaine in White Crystalline Powder	Local Anesthetic Raw Materials Procaine in White Crystalline Powder Basic Info. Product name: Procaine Alias: Procaine hydrochloride; Aminocain...
	Homebrew Injectable Steroids Supertest 450 mg/ml For Muscle Growth Successful Conversion Recipes	Homebrew Injectable Steroids Supertest 450 mg/ml For Muscle Growth Successful Conversion Recipes Basic Info. Supertest 450 mg/ml Testosterone ...
	Oral Anabolic Steroid Hormone Dianabol Methandienone Gain in Muscle Size	Oral Anabolic Steroid Hormone Dianabol Methandienone Gain in Muscle Size Basic Info. Metandienone Alias: Dianabole, Encephan, Geabol, Metanabol...
	Pharmaceutical Raw Materials Indometacin Powder 53-86-1 for Pain Killer Anti Inflammatory	Pharmaceutical Raw Materials Indometacin Powder 53-86-1 for Pain Killer Anti Inflammatory Basic Info. Synonyms: Amuno; Chrono-Indocid 75; Confortid...

Похожие товары

	L-Cystine dihydrochloride in Laboratory & Chemical Industry	Продавец: 846340	L-Cystine dihydrochloride in Laboratory & Chemical Industry Biochemical research reagent Used...
	L-Cystine dihydrochloride in Animal Feed Industry	Продавец: 846340	L-Cystine dihydrochloride in Animal Feed IndustryFeed nutritional additivePromotes growth of live...
	L-Cystine dihydrochloride	Продавец: 846340	L-Cystine dihydrochloride in Cosmetics & Personal Care IndustrySkin conditioning and anti-agi...
	L-Cystine dihydrochloride	Продавец: 846340	L-Cystine dihydrochloride in Food & Health Products IndustryFood nutritional fortifierAdded t...
	L-Cystine dihydrochloride	Продавец: 846340	L-Cystine dihydrochloride in Cell Culture & Biomanufacturing Industry Essential additive in c...