.

Triiodothyronine (T3)

Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.

The determination of triiodothyronine is one of the sensitive indexes in the diagnosis of hyperthyroidism.

When elevating hyperthyroidism, it is also the precursor of the recurrence of hyperthyroidism. In addition, pregnancy and acute hepatitis will advance Hypothyroidism, simple goiter, acute and chronic nephritis, chronic hepatitis, cirrhosis of the liver.

T3 can be used to diagnose t3 antibodies, early detection of hyperthyroidism, and diagnosis of pseudo thyrotoxicosis.

The serum T3 and T4 levels changes are generally consistent, which is a sensitive indicator of thyroid function diagnosis, especially important for early diagnosis. It is a specific diagnostic indicator of T3 hyperthyroidism.

Types Of Triiodothyronine (T3)

Antibody

Application

Sheep Anti-human T3 mAb

For immunodiagnostic: ELISA, LFA, CLIA

Triiodothyronine Intro

As the largest endocrine gland in the human body, the thyroid secretes the main active substances, tetraiodothyronine (T4) and triiodothyronine (T3), which are extremely important for protein synthesis thermoregulation, energy production, and regulation effect.

T3 plays a vital role in judging the physiological condition of the human body, so it is of great significance to detect the content of T3 in serum. The content of T3 in serum is 1/80~1/50 of that of T4, but the biological activity of T3 is 5~10 times that of T4. Most of the T3 in serum is converted from the deiodination of peripheral tissues. A small part of T3 is directly secreted by the thyroid and released into the blood. Most of the T3 in serum is bound to binding proteins. About 90% is bound to thyroxine-binding globulin (TBG), the rest is bound to albumin, and a tiny amount is attached to thyroxine-binding prealbumin (TBPA).

Free T3 Test

Increased T3 is seen in hyperthyroidism, early stage of triiodothyronine-type hyperthyroidism crisis, iodine-deficiency goiter, and hyperthyroid-binding globulinemia.

It is decreased in hypothyroidism, low thyroxine-binding globulinemia, and so on.

High result possible disease: hyperthyroidism.

Low result possible diseases: Hypothyroidism, endocrine proptosis, thyroiditis, resting lymphocytic thyroiditis, hyperthyroidism in children, hyperthyroidism in the elderly, thyroid tuberculosis, endocrine disorders, euthyroid goiter, precocious children Breast hypertrophy.

TT3 Performance Data

Manufacturer

SEKBIO

Parameter

TT3

Linearity

Detection limit

Benchmark product

Roche

Test principle and procedure

TT3: Add 30 μl of sample + 30 μl of Rd, incubation for 10 minutes without cleaning, 30 μl of Ra + 30 μl of Rc and incubation for 5 minutes. Wash with 200 μl of washing solution. Finally, add 100 μl of A + 100 μl of B.

Precision

Sample

RLU

Concentration

Sample

RLU

Concentration

270,946

5

83,336

276,899

79,406

278,536

82,669

259,590

84,427

269,690

81,363

270,230

79,263

257,837

80,565

270,880

77,389

279,936

81,233

271,277

79,113

AVE

AVE

SD

SD

CV

CV

Limit of detection

Sample

RLU

Concentration

Ag Diluent

980,305

1,022,449

0

0

986,963

1,001,873

0

0

984,209

1,003,978

0

0

1,026,252

1,000,042

0

0

1,018,574

961,333

0

0

974,731

982,278

0

0

1,022,323

969,066

0

0

1,071,730

968,489

0

0

1,043,724

1,028,076

0

0

1,014,595

1,014,797

0

0

AVE

SD

AVE+2*SD

0

Linear

Sample(nmol/L)

Dilution ratio

Concentration value

Average

Method Comparison

Reagents Stability

Reagent

Sample(nmol/L)

Average

Deviation

2-8℃

55,377

81,863

340,779

Antigen diluent

666,737

random sample

200,281

calf serum

453,520

37℃ 1d

53,767

-2.91%

83,258

339,943

-0.25%

Antigen diluent

664,104

-0.39%

random sample

188,472

-5.90%

calf serum

459,529

37℃ 3d

51,653

-6.72%

82,714

360,888

Antigen diluent

645,376

-3.20%

random sample

198,372

-0.95%

calf serum

480,304

37℃ 7d

49,977

-9.75%

78,711

-3.85%

366,369

Antigen diluent

629,915

-5.52%

random sample

189,952

-5.16%

calf serum

486,154

Calibrator Stability

Reagent

Sample(nmol/L)

Average

Deviation

2-8℃

43,902

74,473

310,740

37℃ 1d

43,667

76,993

-0.53%

307,831

37℃ 3d

43,303

-0.94%

75,963

-1.36%

306,706

37℃ 7d

44,214

-1.30%

72,454

305,293

-2.71%

As a professional tumor marker factory, SEKBIOhas high-quality tumor markerfor sale. Welcome to contact us if needed.



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