Triiodothyronine (T3)

Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.

The determination of triiodothyronine is one of the sensitive indexes in the diagnosis of hyperthyroidism.

When elevating hyperthyroidism, it is also the precursor of the recurrence of hyperthyroidism. In addition, pregnancy and acute hepatitis will advance Hypothyroidism, simple goiter, acute and chronic nephritis, chronic hepatitis, cirrhosis of the liver.

T3 can be used to diagnose t3 antibodies, early detection of hyperthyroidism, and diagnosis of pseudo thyrotoxicosis.

The serum T3 and T4 levels changes are generally consistent, which is a sensitive indicator of thyroid function diagnosis, especially important for early diagnosis. It is a specific diagnostic indicator of T3 hyperthyroidism.

Types Of Triiodothyronine (T3)

Antibody	Application
Sheep Anti-human T3 mAb	For immunodiagnostic: ELISA, LFA, CLIA

Triiodothyronine Intro

As the largest endocrine gland in the human body, the thyroid secretes the main active substances, tetraiodothyronine (T4) and triiodothyronine (T3), which are extremely important for protein synthesis thermoregulation, energy production, and regulation effect.

T3 plays a vital role in judging the physiological condition of the human body, so it is of great significance to detect the content of T3 in serum. The content of T3 in serum is 1/80~1/50 of that of T4, but the biological activity of T3 is 5~10 times that of T4. Most of the T3 in serum is converted from the deiodination of peripheral tissues. A small part of T3 is directly secreted by the thyroid and released into the blood. Most of the T3 in serum is bound to binding proteins. About 90% is bound to thyroxine-binding globulin (TBG), the rest is bound to albumin, and a tiny amount is attached to thyroxine-binding prealbumin (TBPA).

Free T3 Test

Increased T3 is seen in hyperthyroidism, early stage of triiodothyronine-type hyperthyroidism crisis, iodine-deficiency goiter, and hyperthyroid-binding globulinemia.

It is decreased in hypothyroidism, low thyroxine-binding globulinemia, and so on.

High result possible disease: hyperthyroidism.

Low result possible diseases: Hypothyroidism, endocrine proptosis, thyroiditis, resting lymphocytic thyroiditis, hyperthyroidism in children, hyperthyroidism in the elderly, thyroid tuberculosis, endocrine disorders, euthyroid goiter, precocious children Breast hypertrophy.

TT3 Performance Data

Manufacturer	SEKBIO
Parameter	TT3
Linearity
Detection limit
Benchmark product	Roche
Test principle and procedure	TT3: Add 30 μl of sample + 30 μl of Rd, incubation for 10 minutes without cleaning, 30 μl of Ra + 30 μl of Rc and incubation for 5 minutes. Wash with 200 μl of washing solution. Finally, add 100 μl of A + 100 μl of B.

Precision

Sample	RLU	Concentration	Sample	RLU	Concentration
	270,946		5	83,336
	276,899			79,406
	278,536			82,669
	259,590			84,427
	269,690			81,363
	270,230			79,263
	257,837			80,565
	270,880			77,389
	279,936			81,233
	271,277			79,113
AVE			AVE
SD			SD
CV			CV

Limit of detection

Sample	RLU		Concentration
Ag Diluent	980,305	1,022,449	0	0
	986,963	1,001,873	0	0
	984,209	1,003,978	0	0
	1,026,252	1,000,042	0	0
	1,018,574	961,333	0	0
	974,731	982,278	0	0
	1,022,323	969,066	0	0
	1,071,730	968,489	0	0
	1,043,724	1,028,076	0	0
	1,014,595	1,014,797	0	0
AVE
SD
AVE+2*SD	0

Linear

Sample（nmol/L)	Dilution ratio	Concentration value			Average

Method Comparison

Reagents Stability

Reagent	Sample(nmol/L)	Average	Deviation
2-8℃		55,377
		81,863
		340,779
	Antigen diluent	666,737
	random sample	200,281
	calf serum	453,520
37℃ 1d		53,767	-2.91%
		83,258
		339,943	-0.25%
	Antigen diluent	664,104	-0.39%
	random sample	188,472	-5.90%
	calf serum	459,529
37℃ 3d		51,653	-6.72%
		82,714
		360,888
	Antigen diluent	645,376	-3.20%
	random sample	198,372	-0.95%
	calf serum	480,304
37℃ 7d		49,977	-9.75%
		78,711	-3.85%
		366,369
	Antigen diluent	629,915	-5.52%
	random sample	189,952	-5.16%
	calf serum	486,154

Calibrator Stability

Reagent	Sample(nmol/L)	Average	Deviation
2-8℃		43,902
		74,473
		310,740
37℃ 1d		43,667
		76,993	-0.53%
		307,831
37℃ 3d		43,303	-0.94%
		75,963	-1.36%
		306,706
37℃ 7d		44,214	-1.30%
		72,454
		305,293	-2.71%

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