Acylation of Ferrocene with Adamantoyl Chloride and Cinnamoyl Chloride
Acylation of Ferrocene with Adamantoyl Chloride and Cinnamoyl Chloride
Liquid phase acylation of ferrocene with adamantoyl and cinnamoyl chloride was studied over different structural types of zeolites. The effect of the zeolite structure and acidity, and the influence of the reaction conditions on the ferrocene conversion and selectivity was investigated. The highest ferrocene conversions were achieved over zeolite Beta with Si/Al ratio 12.5 (cinnamoyl chloride 63.5%, adamantoyl chloride 45.9%). It was observed that with decreasing concentration of active sites in zeolite Beta the ferrocene conversion decreases. In addition, it was found that there is an optimum molar ratio of ferrocene to acylating agent, the ferrocene conversion increased with increasing temperature and amount of catalyst. The most important finding is that acylation of ferrocene with adamantoyl and cinnamoyl chloride leads exclusively to monoacylated products, most probably due to a deactivation of the cyclopentadiene rings after the attachment of the first acyl group.
Cinnamyl chloride is obtained by the reaction of sodium cinnamate with oxalyl chloride.
Useof sodium cinnamate:
It can be used in the manufacture of benzyl chloride, cinnamyl chloride, cinnamamide and other intermediates.
At the same time, it is also applicable to improve the cooling system of all kinds of starting machinery, automobile resistance pad, which is beneficial to the long distance use of automobile.
It can also be used in pharmaceutical intermediates and cosmetics.
Sodium cinnamate is soluble in water and is a good food preservative.
Sodium Cinnamate is a pharmaceutical intermediate for the anticoagulant ozagrel.
This product can be used as photosensitive material!
Production Methodsof Acetyl chlorid
In industry, acetyl chloride can be prepared by the reaction of ethylene with hydrogen chloride, or by the reaction of sodium acetate, sulfur dioxide with chlorine. Laboratories can be prepared by the reaction of acetic acid, sodium acetate or acetic anhydride with various chlorinating agents.
Useof sodium Acetyl chloride
Acetyl chloride is used in the manufacture of organic compounds, dyes and pharmaceuticals. Acetyl chloride can be produced industrially by the reaction of acetone with hydrogen chloride, or by the reaction of sodium acetate and sulfur dioxide with chlorine. Acetyl chloride can be prepared in the laboratory by the reaction of acetic acid, sodium acetate or acetic anhydride with various chlorinating agents. It is stronger than acetic anhydride and is widely used in organic synthesis. Acetyl chloride is also a catalyst for chlorination of carboxylic acids and can be used for quantitative analysis of hydroxyl or amino groups.
Acetyl chloride is an important organic synthesis intermediate and acetylation reagent. It has stronger acylation ability than acetic anhydride. It is widely used in organic synthesis. It can be used in the production of pesticides, medicines, new plating complexing agents, and many other fine organic synthesis intermediates. It can be used in medicine to prepare 2,4-dichloro-5-fluoroacetophenone (intermediate of ciprofloxacin), ibuprofen. Acetyl chloride is also a catalyst for chlorination of carboxylic acids.
For organic synthesis, dyes, pharmaceuticals and other industries.
Used as analytical reagent as well as in the preparation of acetyl derivatives and dyes
Is an acetylating agent, used as a raw material for pesticides and medicine, or an intermediate for the manufacture of water treatment agent, ethylenediphosphate.
It is also used as a raw material for pesticide and medicine, as an intermediate in the manufacture of water treatment agent, ethylenediphosphate, and in the manufacture of new electroplating complexing agent. Acetyl chloride is an important acetylation reagent, acylation ability is stronger than acetic anhydride, widely used in organic synthesis, dyes. It is also a catalyst for chlorination of carboxylic acids and can be used for quantitative analysis of hydroxyl and amino groups. Determination of water in cholesterol and organic liquid, determination of hydroxyl tetraethyl lead, identification of nitroso. Used as acetylation reagent. Dye synthesis for pharmaceutical use.
Oxaloyl chloride
After mixing anhydrous oxalic acid and phosphorus pentachloride, heating slowly to about 64, reaction to anhydrous hydrogen chloride. Oxaloyl chloride is obtained after distillation of crude product. Or reacted with oxalic acid with carboyl chloride (phosgene).
Acetylchloride is used as intermediate for the synthesis of benzoylurea insecticide flutamide and chlorpropanone, and is also the intermediate of sulfonylurea herbicide methyl sulfuron, bensulfuron-methyl, pyrisulfuron and so on. Acetyl chloride is a widely used acylation reagent for the preparation of carboyl chloride, phosphoryl dichloride, chlorinated alkanes and acyl isocyanate.
Stability and toxicity
oxaloyl chloride is not only sensitive to air, but also has an unpleasant taste. Oxaloyl chloride is highly toxic and corrosive and can severely irritate the eyes, skin and respiratory tract. Reagents containing oxaloyl chloride must be kept in a cool, dry environment and sealed strictly. Contact with moisture is strictly prohibited. Oxaloyl chloride reacts violently with water, giving off toxic gases: carbon monoxide, carbon dioxide, and hydrogen chloride.
The intermediates used in the synthesis of benzoylurea insecticides flubolylurea and chlorproylurea are also the intermediates of sulfonylurea herbicides methyl sulfuron-methyl pyripyridamuron and so on. Oxaloyl chloride is a widely used acylation reagent for the preparation of carboyl chloride, phosphoryl dichloride, chlorinated alkanes and acyl isocyanate.
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