Reducing Fat Mass Chemicals Sr9011 CAS Pharmaceutical Grade

• 

Reducing Fat Mass Chemicals Sr9011 CAS Pharmaceutical Grade Basic Info: Cas No Synonyms 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-1-carboxamide Formula C23H31ClN4O3S Molucelar weight 479.03524 Product Description: SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates. SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols. Usage levels of 5% to 10% by weight are recommended. SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV ERB α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases. Application: In vitro: SR9011 was used at 5-10 μM concentration in vitro and in cellular assays. In vivo: IP administration of SR9011 was used at 100 mg/kg once or twice per day for 12-30 days in different mouse models.

Other supplier products

	Pharmaceutical Raw Materials Mitotan CAS 53-19-0 Used to Antineoplastic Agent	Pharmaceutical Raw Materials Mitotan CAS 53-19-0 Used to Antineoplastic Agent Basic info: Mitotane CAS:53-19-0 MF:C14H10Cl4 MW:320.04 EINECS:20...
	99% Purity Raw Steroid Powders CAS 1424-00-6 Mesterolone for Bodybuilding Steroids	99% Purity Raw Steroid Powders CAS 1424-00-6 Mesterolone for Bodybuilding Steroids Basic Info. CAS: 1424-00-6 Synonyms: 17-beta-hydroxy-1-alpha-...
	Pharmaceutical Raw Materials Female Steroids Raw Hormone Powders Mifepristone CAS 84371-65-3	Pharmaceutical Raw Materials Female Steroids Raw Hormone Powders Mifepristone CAS 84371-65-3 Basic Info. Mifepristone CAS Number: 84371-65-3 Mol...
	Pharmaceutical Intermediate Anti-Estrogen Clomiphene Citrate Steroid Hormone Powder Clomid	Pharmaceutical Intermediate Anti-Estrogen Clomiphene Citrate Steroid Hormone Powder Clomid Basic Info. Clomiphene Citrate Alias: Clomid CAS No: ...
	521-12-0 Masteron Legal Raw Steroid Powder Drostanolone Propionate for Muscle Building	521-12-0 Masteron Legal Raw Steroid Powder Drostanolone Propionate for Muscle Building Basic Info. Drostanolone Propionate Synonyms: Masteron; D...

Same products

	Bosnia and Herzegovina liquid nitrogen tank for laboratory KGSQ	Seller: Henan Tianzhidao Biological Technology Co., Ltd	In laboratories, most commonly used liquid nitrogen tanks have large capacity, large diameter, an...
	Tanzania sperm cell storage KGSQ ln2 vessel	Seller: Henan Tianzhidao Biological Technology Co., Ltd.	In laboratories, most commonly used liquid nitrogen tanks have large capacity, large diameter, an...
	Ebike Battery	Seller: Shenzhen Worldpower Energy Storage Technology Co.,Ltd	Custom Ebike Lithium Battery Manufacturer Elevate your electric biking experience with Worldpowe...
	Battery Energy Storage Systems	Seller: Shenzhen Worldpower Energy Storage Technology Co.,Ltd	Battery Energy Storage Systems (BESS) are cutting-edge technologies that store electrical energy ...
	ETH Ethereum Jasminer X4 BRICK ASIC Miner	Seller: Shenzhen Dovina Electronic Co.,Ltd	Jasminer X4 Brick Review Jasminer x4 brick for salefrom Jasminer mining EtHash algorithm with a ...