Reducing Fat Mass Chemicals Sr9011 CAS Pharmaceutical Grade

• 

Reducing Fat Mass Chemicals Sr9011 CAS Pharmaceutical Grade Basic Info: Cas No Synonyms 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-1-carboxamide Formula C23H31ClN4O3S Molucelar weight 479.03524 Product Description: SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates. SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols. Usage levels of 5% to 10% by weight are recommended. SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV ERB α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases. Application: In vitro: SR9011 was used at 5-10 μM concentration in vitro and in cellular assays. In vivo: IP administration of SR9011 was used at 100 mg/kg once or twice per day for 12-30 days in different mouse models.

Other supplier products

	Pharmaceutical Trenbolone Steroids Parabolan 10161-33-8 Trenbolone Enanthate for Weight Loss	Pharmaceutical Trenbolone Steroids Parabolan 10161-33-8 Trenbolone Enanthate for Weight Loss Basic Info. Product Name: Trenbolone Enanthate Alias...
	Pharmaceutical Raw Materials Desonide CAS 638-94-8 Used To Treat Atopic Dermatitis	Pharmaceutical Raw Materials Desonide CAS 638-94-8 Used To Treat Atopic Dermatitis Basic info: Desonide CAS NO.: 638-94-8 EINECS: 211-351-6 Mole...
	Factory Direct Supplying Top Quality Anabolic Steroids Powder Drospirenone 67392-87-4	Factory Direct Supplying Top Quality Anabolic Steroids Powder Drospirenone 67392-87-4 Basic Info. Product Name: Drospirenone Synonyms: arbolacto...
	Anabolic Bodybuilding Supplements Raw Steroid Powders Letrozole Femara for Breast Cancer	Anabolic Bodybuilding Supplements Raw Steroid Powders Letrozole Femara for Breast Cancer Basic Info. Letrozol-e Alias:Letrazol-e; Letrozol-e Fem...
	99.9% Pramoxine Hydrochloride Anesthetic Anodye CAS 637-58-1 Pramoxine HCl	99.9% Pramoxine Hydrochloride Anesthetic Anodye CAS 637-58-1 Pramoxine HCl Basic Info. English name: Pramoxine Hydrochloride CAS: 637-58-1 EINE...

Same products

	2UUL SP01 Grip X Phone Screen Heating Separator with Suction Pad	Seller: SHENZHEN PHONEFIX TECHNOLOGY CO.,LTD (CHINA PHONEFIX)	Professional repair efficiency starts with precision tools. Introducing the YCS integrated BGA...
	2UUL SP01 Grip X Phone Screen Heating Separator with Suction Pad	Seller: SHENZHEN PHONEFIX TECHNOLOGY CO.,LTD (CHINA PHONEFIX)	Professional repair efficiency starts with precision tools. Introducing the YCS integrated BGA...
	Anti Insect Net	Seller: Shandong Gold Hongye Net Co., Ltd	Anti Insect netis suitable for plants of different sizes, indoor and outdoor gardens, and effecti...
	FT wax used in plastics: injection moulding, extrusion and pelletisation	Seller: Syntop chemical Co.,Ltd.	Fischer-Tropsch wax is widely used in plastics processing, particularly in industries such as inj...
	Fischer Tropsch wax used for the processing of leather care products	Seller: Syntop chemical Co.,Ltd.	Fischer Tropsch wax plays a significant role in the formulation of leather care products, primari...