Reducing FReducing Fat Mass Chemicals Sr9011 CAS Pharmaceutical Gradeat Mass Chemicals Sr9011 CAS Pharmaceutical Grade
Reducing Fat Mass Chemicals Sr9011 CAS Pharmaceutical Grade
Basic Info:
Cas No
Synonyms 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-1-carboxamide
Formula C23H31ClN4O3S
Molucelar weight 479.03524
Product Description:
SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates.
SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols. Usage levels of 5% to 10% by weight are recommended.
SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV ERB α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.
Application:
In vitro: SR9011 was used at 5-10 μM concentration in vitro and in cellular assays.
In vivo: IP administration of SR9011 was used at 100 mg/kg once or twice per day for 12-30 days in different mouse models.
在线联系供应商
Other supplier products
 |
High Purity Body Supplement Kola Nut Extract/Cola Acuminata Powder | High Purity Body Supplement Kola Nut Extract/Cola Acuminata Powder Basic Info. Latin Name: Cola acuminata CAS No.: 68916-19-8 Active Ingredient... |
 |
Pharmaceutical Grade Epicatechin White Powder CAS 490-46-0 L-Epicatechin | Pharmaceutical Grade Epicatechin White Powder CAS 490-46-0 L-Epicatechin Basic Info. Product Name: L-Epicatechin Synonym: 2-(3, 4-dihydroxyphen... |
 |
Anabolic Androgenic Steroids Boldenone Steroids Powder CAS 846-48-0 Boldenone Base | Anabolic Androgenic Steroids Boldenone Steroids Powder CAS 846-48-0 Boldenone Base Basic Info. Product Name: Boldenone Synonyms: Boldenone; Bold... |
 |
99% Purity Peptide Triptorelin for Muscle Building | 99% Purity Peptide Triptorelin for Muscle Building Basic Info. Product Name: Triptorelin Synonyms: PGLU-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH... |
 |
Pharmaceutical Raw Materials Prednisolone 50-24-8 | Pharmaceutical Raw Materials Prednisolone 50-24-8 Basic Info. Product name: Prednisolone Synonyms: Hydrodeltalone Hydrodeltisone Hydroretrocort... |
Same products
 |
2UUL SP01 Grip X Phone Screen Heating Separator with Suction Pad | 卖方: 深圳市维客修科技有限公司 | Professional repair efficiency starts with precision tools. Introducing the YCS integrated BGA... |
 |
2UUL SP01 Grip X Phone Screen Heating Separator with Suction Pad | 卖方: 深圳市维客修科技有限公司 | Professional repair efficiency starts with precision tools. Introducing the YCS integrated BGA... |
 |
Anti Insect Net | 卖方: Shandong Gold Hongye Net Co., Ltd | Anti Insect netis suitable for plants of different sizes, indoor and outdoor gardens, and effecti... |
 |
FT wax used in plastics: injection moulding, extrusion and pelletisation | 卖方: Syntop chemical Co.,Ltd. | Fischer-Tropsch wax is widely used in plastics processing, particularly in industries such as inj... |
 |
Fischer Tropsch wax used for the processing of leather care products | 卖方: Syntop chemical Co.,Ltd. | Fischer Tropsch wax plays a significant role in the formulation of leather care products, primari... |
